Evidence map›Paper›PMID 42192905›Full record

ArticleCancers2026

Association of Iba1-Positive Macrophages and B7-H3-Positive Tumor Cells with Tumor Growth Kinetics in WHO Grade II Meningioma: A Pilot Watch-and-Wait Cohort Study.

Eiji Ito, Masasuke Ohno, Mao Yokota, Shunichiro Kuramitsu, Toru Nagasaka, Toshiaki Inomo, Tadashi Watanabe, Mitsugu Fujita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eiji ItoDepartment of Neurosurgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute 480-1195, Japan.
Masasuke OhnoDepartment of Neurosurgery, Aichi Cancer Center, 1-1 Shikanodono, Chikusa-ku, Nagoya 464-8681, Japan.ORCID 0000-0002-3026-7959
Mao YokotaDepartment of Neurosurgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute 480-1195, Japan.
Shunichiro KuramitsuDepartment of Neurosurgery, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan.
Toru NagasakaAssociation of Medical Artificial Intelligence Curation, Sakae Members Office Building, Room 505, 4-16-8 Sakae, Naka-ku, Nagoya 460-0008, Japan.
Toshiaki InomoDepartment of Neurosurgery, Tsushima City Hospital, 3-73 Tachibana-cho, Tsushima 496-0038, Japan.
Tadashi WatanabeDepartment of Neurosurgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute 480-1195, Japan.
Mitsugu FujitaCenter for Medical Education and Clinical Training, Kindai University Faculty of Medicine, 1-14-1 Miharadai, Minami-ku, Sakai 590-0197, Japan.ORCID 0000-0002-0000-9879

Funding

Japan Society for the Promotion of Science 23K15677Japan Society for the Promotion of Science 24K10381Japan Society for the Promotion of Science 24K12219Japan Society for the Promotion of Science 25K12376
6 · The paper itself

Abstract

BACKGROUND/

objectivesWHO grade II meningiomas show highly variable growth rates that are difficult to predict using conventional histology. We investigated relationships between immune components within the tumor immune microenvironment (TIME) and explored their association with tumor growth kinetics.

methodsWe retrospectively evaluated a small, preselected cohort of 15 patients with WHO grade II meningiomas who underwent initial "watch-and-wait" observation with serial preoperative MRI. Notably, this cohort represents a specific clinical subset-tumors deemed initially observable-and may not be representative of all WHO grade II meningiomas. Densities of Iba1-positive macrophages (TAMs) and B7-H3-positive tumor cells were quantified by digital pathology. The relative growth rate (RGR) was calculated from serial MRI.

resultsA strong inverse correlation was observed between TAM density and B7-H3-positive tumor cell density (Spearman's

conclusionsOur findings generate the hypothesis that WHO grade II meningiomas exhibit an inverse relationship between TAMs and B7-H3 and that macrophage-poor/B7-H3-high and macrophage-rich/B7-H3-low patterns may differ in preoperative growth behavior. These observations are derived from a small, preselected cohort of tumors managed with an initial "watch-and-wait" strategy and require validation in broader populations.

Indexed as

B7-H3immunophenotypeprognosistumor-associated macrophagestumor growth kineticstumor immune microenvironmentWHO grade II meningioma

Identifiers

PMID42192905
PMCPMC13204069

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