Evidence map›Paper›PMID 42192869›Full record

ArticleCancers2026

Hypoxia Impairs CD8

Ashley M Mello, Marina Pasca di Magliano, Kyoung Eun Lee

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashley M MelloProgram in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3280-181X
Marina Pasca di MaglianoRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Kyoung Eun LeeRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3955-7389

Funding

Role of hypoxia in CD8+ T cell exclusion and suppression in pancreatic cancerF31CA281079 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ashley Mello · 2023 to 2026
$167k
NCI NIH HHS F31 CA281079NIH HHS 5R01CA269025-03University of Michigan Rogel Cancer Center Rogel Scholar Award
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stromal microenvironment and profound hypoxia, which contribute to therapeutic resistance. Using an in vitro system incorporating pancreatic cancer cells and cancer-associated fibroblasts (CAFs), we show that hypoxia suppresses CD8

Indexed as

apoptosisCD8+ T celldifferentiationexhaustionfibroblasthypoxiapancreatic cancerproliferation

Identifiers

PMID42192869
PMCPMC13204382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.