Evidence map›Paper›PMID 42192831›Full record

ArticleBrain sciences2026

Mapping the Human Performance Envelope Through Multivariate Information Transfer.

Gianluca Borghini, Khadija Latrach, Gianluca Di Flumeri, Pietro Aricò, Vincenzo Ronca, Andrea Giorgi, Rossella Capotorto, Alessia Ricci, Stefano Bonelli, Vanessa Arrigoni and 5 more

Abstract read
In one paragraph

Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gianluca BorghiniDepartment of Molecular Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0001-8560-5671
Khadija LatrachDepartment of Molecular Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
Gianluca Di FlumeriDepartment of Molecular Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0003-4426-051X
Pietro AricòDepartment of Computer, Control, and Management Engineering Antonio Ruberti, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0002-3831-6620
Vincenzo RoncaDepartment of Computer, Control, and Management Engineering Antonio Ruberti, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0002-7174-6331
Andrea GiorgiDepartment of Molecular Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0001-6220-3389
Rossella CapotortoDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0009-0005-0842-2915
Alessia RicciDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0009-0006-5784-234X
Stefano BonelliDeepBlue srl, Piazza Buenos Aires 20, 00185 Rome, Italy.ORCID 0000-0003-4499-3772
Vanessa ArrigoniDeepBlue srl, Piazza Buenos Aires 20, 00185 Rome, Italy.
Paola TomaselloDeepBlue srl, Piazza Buenos Aires 20, 00185 Rome, Italy.
Fabrice DrogoulEUROCONTROL, Rue de la Fusée 96, 1130 Brussels, Belgium.
Jean Paul ImbertAeronautical Computer Human Interaction Lab (ACHIL), École Nationale de l'Aviation Civile, 7 Avenue Edouard Belin, 31000 Toulouse, France.ORCID 0000-0001-5082-1374
Géraud GrangerAeronautical Computer Human Interaction Lab (ACHIL), École Nationale de l'Aviation Civile, 7 Avenue Edouard Belin, 31000 Toulouse, France.
Fabio BabiloniDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0002-4962-176X

Funding

European Council 950998
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe human performance envelope (HPE) is a multidimensional model that represents the range in which an individual operator's performance is acceptable or begins to become dangerous. Although several alternative models have been proposed, HPE currently remains primarily a theoretical concept. The goal of the study was therefore to translate this theoretical concept into practical applications, seeking to characterize and measure how HPE manifests itself in real-world contexts.

methodsMultivariate Autoregressive (MVAR) models and conditional transfer entropy (cTE) have been used in the analysis of complex systems in which processes are interdependent and mutually influence their dynamics over time. Professional Air Traffic Controllers were involved in the study and asked to deal with realistic traffic scenarios while their behavioural, subjective and neurophysiological data were collected. MVAR-cTE models were then employed to estimate the interactions among controller human factors and to identify the most appropriate characterization of the HPE.

resultsThe results showed high and significant correlations among each controller's performance and the corresponding neurophysiological-based HPE values. Furthermore, high-performance conditions (best) were characterized by significantly higher HPE values and higher inter-human factor connections compared to the low-performance (worst) status. This evidence suggested that a densely interconnected network of Human Factors is a prerequisite for operational resilience.

conclusionsThe study provided the first application of a neurophysiological framework to model the directed interactions between human factors, translating the theoretical HPE into a quantifiable model validated against operator performance.

Indexed as

air traffic controller (ATCO)conditional transfer entropy (cTE)human factors (HF)human performance envelope (HPE)Least Absolute Shrinkage and Selection Operator (LASSO)mental statesneurophysiological

Identifiers

PMID42192831
PMCPMC13205029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.