ArticleBrain sciences2026
Structural and Connectivity Alterations of the Premotor Cortex in Autistic Children: Implications for Affective Motor Impairments.
Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
When people interact, their actions reflect mood, attitude, and intention. Stern termed the affective qualities conveyed by actions, such as gentleness or rudeness, Vitality Forms (VFs). Previous research shows that children with autism spectrum disorder (ASD) differ from neurotypical (NT) peers in both perceiving and expressing these fundamental aspects of communication. It remains unclear whether these differences arise from structural or connectivity alterations in brain regions involved in VF processing. This study investigated structural and microstructural brain differences between children with ASD and NT peers, focusing on the VF-related network, which includes the dorso-central insula (DCI), premotor cortex (PM), middle cingulate cortex (MCC), and dorsolateral prefrontal cortex (DLPFC). Structural MRI data were collected from 60 right-handed boys aged 6-10 years (30 ASD, 30 NT), with diffusion MRI data available for a subset (20 ASD, 20 NT). A multimodal approach combined voxel-based morphometry (VBM), tract-based spatial statistics (TBSS), and probabilistic tractography. VBM revealed increased grey-matter volume in the PM, DLPFC, and MCC in the ASD group, with no differences in the DCI. TBSS showed white-matter microstructural alterations in premotor-related pathways. Probabilistic tractography further indicated atypical organization of tracts connecting the PM with the DLPFC, MCC, and DCI in children with ASD. Overall, the findings suggest atypical development of the premotor cortex and its associated white-matter connections in ASD, supporting theoretical accounts that link this network to altered processing of affective action dynamics during social interaction.
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