Evidence map›Paper›PMID 42192466›Full record

ArticleJournal of translational medicine2026

RYR1

Xin Zhang, Christopher G Vann, David B Bartlett, Alastair Khodabukus, George A Truskey, Nenad Bursac, Joseph A Houmard, Johanna L Johnson, Kim M Huffman, Brian J Andonian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin ZhangDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu.ORCID 0000-0001-7390-4439
Christopher G VannDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
David B BartlettDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
Alastair KhodabukusDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
George A TruskeyDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Nenad BursacDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Joseph A HoumardDepartment of Kinesiology, Human Performance Laboratory, East Carolina University, Greenville, North Carolina, USA.
Johanna L JohnsonDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
Brian J AndonianDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
Virginia Byers KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.

Funding

Extracellular Vesicle Analyses to Develop Aging and Resilience BiomarkersR01AG070146 · NIA · DUKE UNIVERSITY · PI KRAUS, VIRGINIA B · 2021 to 2025
$3.1M
Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic HealthR01HL153497 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2021 to 2024
$2.8M
NHLBI NIH HHS R01 HL153497NIA NIH HHS R01 AG070146
6 · The paper itself

Abstract

backgroundSkeletal muscle is a central regulator of insulin sensitivity and glucose homeostasis. The ryanodine receptor 1 (RYR1) is highly expressed in skeletal muscle and plays a key role in myogenic differentiation. We hypothesize that RYR1

methodsWe tested this hypothesis through in vitro analyses of smRNAs of skeletal muscle-derived EVs and in vivo evaluation of their exercise responsiveness and association with insulin action in older adults. Using an integrated workflow combining centrifugation, polymer-based precipitation, and single-EV sorting, we isolated RYR1

resultsBy smRNA sequencing, compared to myobundle RYR

conclusionsThese complementary in vitro and in vivo data identify skeletal muscle-derived RYR1

Indexed as

ExerciseExtracellular VesiclesInsulinMuscle, SkeletalRyanodine Receptor Calcium Release ChannelAgedAgingBiomarkersFemaleHumansMaleMicroRNAsBiomarkersInsulinMicroRNAsRyanodine Receptor Calcium Release ChannelRYR1 protein, humanExerciseExtracellular vesiclesHOMA-IRInsulinMiRNApiRNASingle vesicle sortingSkeletal muscle

Identifiers

PMID42192466
PMCPMC13217694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.