ArticleBMC microbiology2026
Comparative genomics of Sneathia species: insights into pathogenicity and adaptation to the human niche.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSneathia are urogenital anaerobes linked to bacterial vaginosis, preterm birth, chorioamnionitis, urethritis, and HPV-mediated cervical carcinogenesis. Two species have been identified: Sneathia vaginalis and Sneathia sanguinegens. Yet, due to their fastidious nature, our knowledge of their pathogenicity is limited.
methodsComparative genomic analysis of 12 Sneathia genomes, including two newly sequenced via whole-genome sequencing, was used to evaluate the pathogenic potential of S. vaginalis and S. sanguinegens.
resultsSneathia species have small genomes (1.25-1.35 Mbp) with low (26.7-29.0%) GC content. The genomes of both species harbor a similar number of subsystems, mostly related to protein processing, metabolism, and energy. Both species encode subsystems for glycogen utilization and lactic and mixed acid fermentation. The genomes of S. vaginalis exhibit a higher potential for carbohydrate and carbohydrate derivative metabolism (gluconate and ascorbic acid catabolism, the Entner-Doudoroff pathway) providing a competitive advantage in nutrient-limited environments. S. sanguinegens genomes show a higher potential for amino sugar (hyaluronic acid and N-acetylneuraminic acid catabolism) and sulfur-containing amino acid metabolism. Sneathia species also encode unique subsystems related to stress response, including oxidative stress, heat shock, and antibiotic resistance. Finally, Sneathia genomes encode both core (shared by all strains) and accessory (specific for species or strains) virulence factors, including exotoxin, additional hemolysins, O-sialoglycoprotein endopeptidase, and adhesins.
conclusionsBoth S. vaginalis and S. sanguinegens are highly adapted to the urogenital niche and exhibit high pathogenic capacities. Genomic information revealed potential mechanisms by which these pathogens enhance their competitiveness within the urogenital tract and likely facilitate microbe-microbe cooperation in polymicrobial communities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.