Observational studyCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026
PCI for Ostial Stenosis of Left Circumflex or Left Anterior Descending Artery.
Observational study in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo date, the clinical outcome of ostial stent implantation (OSI) in patients with ostial left circumflex artery (LCX) or left anterior descending artery (LAD) lesions has not been well established. This study sought to assess the cardiovascular outcomes of the ostial stent implantation (OSI) for the ostial LAD or LCX lesions under long-term follow-up.
methodsThis large-scale, multicenter (n = 13) observational, retrospective study included 839 patients (men: 619 [73.8%], mean age: 61.36 ± 11.93 years) who underwent PCI with OSI for ostial LAD or LCX lesions between 2014 and 2025. The primary outcome was major adverse cardiac events (MACE), including cardiac death, target lesion revascularisation, and target vessel myocardial infarction.
resultsThe study cohort was divided into two groups: ostial LAD (n = 590) and ostial LCX (n = 249) revascularized with OSI. SYNTAX scores and the utilization of intravascular imaging rates were similar in both groups. Total stent length (22.79 ± 7.37 vs. 24.60 ± 7.57 mm, p = 0.001) was notably lower in the LCX group; however, the rate of bailout 2-stent technique (6.4 vs. 2.7%, p = 0.010) was significantly higher in the LCX group than in the LAD group. The risk-adjusted long-term MACE (HR: 1.591, p = 0.010) significantly differed in individuals with left-sided ostial lesions to revascularize with OSI. Additionally, diabetes mellitus, chronic kidney disease, intravascular imaging, reduced left ventricle ejection fraction, high SYNTAX score, statin usage, and total stent length were found to be independent predictors of MACE.
conclusionsThis multicenter study demonstrates that the location of ostial stenosis in LCX was associated with a higher risk-adjusted MACE rate at long-term follow-up.
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