ArticleScientific reports2026
Design, click-based synthesis, molecular docking, molecular dynamics and anticancer activity of new isoindoline-1,3-dione- triazole-glycopyranosyl hybrids.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The application of simulated research approaches for the discovery and development of novel compounds as promising cancer drug candidates have still garnered widespread attention as an important goal in medicinal chemistry. In such context, a novel derived series of modified glycosides based on an isoindole-1,2,3-triazole-1,4-disubstituted-aryl hybrid system were synthesized from the terminal acetylenic compound (prepared from propargylation of 2-(4-hydroxyphenyl)isoindoline-1,3-dione (1)) and different glycosyl azides via click-based strategy. Furthermore, the afforded acetylated Iso-idolinedione-N
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