ArticleNature communications2026
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma.
Abstract read
In one paragraph
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- From the energy factory to the intercellular communication medium: the emerging role of intercellular mitochondrial transfer and mitochondrial transplantation therapy in diabetes and diabetic complications.Journal of translational medicine · 2026Review
- Therapeutic and diagnostic potential of extracellular vesicle (EV)-mediated intercellular transfer of mitochondria and mitochondrial components.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Transmitophagy in the heart: An overview of molecular mechanisms and implications for pathophysiology.Acta pharmaceutica Sinica. B · 2026Review
- Extracellular Vesicles & Co.: scaring immune cells in the TME since ever.Frontiers in immunology · 2024Review
Corrections and comments
- Update of
Authors and funding
29 authors.
Kenneth P HoughDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer L TrevorDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Shaheer AhmadDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Yong WangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Balu K ChackoMitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kayla F GoliwasDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
John G StrenkowskiDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Yuelong LiuDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Joanna I NowakDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Eugene J BeckerDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Young-Il KimDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Renita HolmesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Nathaniel B BoneDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Shia VangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Alexandra PritchardDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jay ChinDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Sandeep BodduluriDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Veena B AntonyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-2326-352X
Sultan TousifDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Mohammad AtharDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Diptiman ChandaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Kasturi MitraDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Jaroslaw W ZmijewskiDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jianhua ZhangMitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-2128-9574
Steven R DuncanDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Victor J ThannickalDepartment of Medicine, Tulane University School of Medicine and the Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA.ORCID http://orcid.org/0000-0003-4266-8677
Susanne GabrielssonDivision of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1771-1346
Victor M Darley-UsmarMitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jessy S DeshaneDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. treena@uab.edu.ORCID http://orcid.org/0000-0002-6761-5662
Funding
UAB Research Center of Excellence in ArsenicalsU54ES030246 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2018 to 2022
$19.0MSex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID B ALLISON · 2015 to 2026
$11.3MAMPK in the Development and Resolution of Lung FibrosisR01HL139617 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Victor J. Thannickal, Jaroslaw Waldemar Zmijewski · 2019 to 2026
$4.4MMetabolic Reprogramming of the Alveolar Stem Cell Niche in Pulmonary FibrosisR01HL173154 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI Victor J. Thannickal · 2024 to 2026
$1.8MMyeloid-Derived Regulatory Cells in AsthmaR01HL128502 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DESHANE, JESSY SATYADAS · 2016 to 2020
$1.8MFlight Attendant Medical Research Institute (Flight Attendant Medical Research Institute, Inc.) YCSA 2010Francis Family Foundation Parker B. Francis FellowshipHjärt-Lungfonden (Swedish Heart-Lung Foundation) 20200646Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 20230528NHLBI NIH HHS R01 HL128502NHLBI NIH HHS R01 HL139617NHLBI NIH HHS R01 HL173154NIA NIH HHS P30 AG050886NIEHS NIH HHS U54 ES030246U.S. Department of Defense (United States Department of Defense) HT9425-24-1-0304U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL139617U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL173154U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL128502U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ES030246-01U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG050886Vetenskapsrådet (Swedish Research Council) 2022-01170
Abstract
Small extracellular vesicles (sEVs) orchestrate cell-cell communication, but the role of sEV signaling via mitochondria in perpetuating asthmatic airway inflammation is unknown. Myeloid-derived regulatory cells (MDRCs) control CD4
Indexed as
AsthmaExtracellular VesiclesMitochondriaT-Lymphocytes, Helper-InducerAnimalsDynaminsFemaleHumansLymphocyte ActivationMiceMice, Inbred C57BLMitochondrial DynamicsNF-kappa BReceptors, Antigen, T-CellSignal TransductionTh17 CellsDNM1L protein, humanDynaminsNF-kappa BReceptors, Antigen, T-Cell
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.