Evidence map›Paper›PMID 42192116›Full record

ArticleNPJ Parkinson's disease2026

Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson's disease.

Yi-Yan Sun, Hua-Mei Lin, Jie Ma, Zhi-Jie Xu, Xin Xue, Juan-Juan Lu, Jia-Jia Wu, Xu-Yun Hua, Chuan-Tao Zuo, Jian-Guang Xu

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In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-Yan Sun *Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hua-Mei Lin *Department of Nuclear Medicine/PET center, Huashan Hospital, Fudan University, Shanghai, China.
Jie Ma *Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhi-Jie XuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xin XueDepartment of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Juan-Juan LuDepartment of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jia-Jia Wu *Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. wujiajia@shutcm.edu.cn.
Xu-Yun Hua *Department of Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. huaxuyun@shutcm.edu.cn.
Chuan-Tao ZuoDepartment of Nuclear Medicine/PET center, Huashan Hospital, Fudan University, Shanghai, China. zuochuantao@fudan.edu.cn.
Jian-Guang XuDepartment of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. xjg@shutcm.edu.cn.

Funding

High-level Chinese Medicine Key Discipline Construction Project (Integrative Chinese and Western Medicine Clinic) of National Administration of TCM zyyzdxk-2023065National Key R&D Program of China 2024YFC3507102National Natural Science Foundation of China 82172554National Natural Science Foundation of China 82272583National Natural Science Foundation of China 82272589National Natural Science Foundation of China 82302870, 82472589National Natural Science Foundation of China 82402991Shanghai Hospital Development Center Foundation-Shanghai Municipal Hospital Rehabilitation Medicine Specialty Alliance SHDC22023304Shanghai Innovative Medical Device Application Demonstration Project 23SHS05600Shanghai Municipal Health Commission Collaborative Innovation Group 2024CXJQ03Shanghai Oriental Talents Program QNJY2024077Shanghai Oriental Talents Program QNWS2024084Shanghai Oriental Talents Program QNWS2025092Shanghai Rising-Star Program 23QA1409200Shanghai Rising-Star Program 24QA2709300Shanghai Special Fund for Promoting High-Quality Industrial Development 240404, 2025-GZL-RGZN-01035Shanghai Talent Development Fund 2021074
6 · The paper itself

Abstract

Motor impairment in Parkinson's disease (PD) is classically attributed to striatal dopaminergic degeneration, yet dopamine loss alone does not fully explain symptom severity, suggesting a key role for circuit-level mechanisms. The cortico-basal ganglia-thalamo-cortical (CBGTC) system is central to dopaminergic motor modulation, but whether dysfunction within individualized CBGTC circuits mediates motor severity across disease stages remains unclear. Here, we studied 76 PD patients (40 mild, 36 moderate-to-severe) who underwent

Identifiers

PMID42192116
PMCPMC13487261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.