Evidence map›Paper›PMID 42192057›Full record

ArticleMagma (New York, N.Y.)2026

Fat-suppressed quantitative ultrashort echo time magnetization transfer (UTE-MT) imaging of the knee joint.

Soo Hyun Shin, Jiyo S Athertya, Jiaji Wang, James Lo, Sheronda M Statum, Christine B Chung, Yajun Ma, Jiang Du

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Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Soo Hyun ShinDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
Jiyo S AthertyaDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
Jiaji WangDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
James LoDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
Sheronda M StatumDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
Christine B ChungDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
Yajun MaDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA.
Jiang DuDepartment of Radiology, University of California, San Diego, 9452 Medical Center Drive , La Jolla, CA, 92037, USA. jiangdu@health.ucsd.edu.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Ultrashort Echo Time Magnetic Resonance Imaging of the Knee JointR01AR085008 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jiang Du · 2025 to 2026
$1.3M
NIAMS NIH HHS R01AR079484NIAMS NIH HHS R01AR085008
6 · The paper itself

Abstract

objectiveTo develop a simple fat-suppression strategy for more accurate quantitative ultrashort echo time magnetization transfer (UTE-MT) imaging of knee joint tissues. MATERIALS AND

methodsA narrow-bandwidth RF pulse centered on the fat peak was utilized for fat-selective imaging. These fat-selective images were subsequently subtracted from the MT-weighted 3D-UTE images to mitigate fat contamination in knee joint tissue imaging. This method was evaluated in an ex vivo human knee specimen and in three healthy volunteers at 3 T. Voxel-wise and ROI-based quantitative MT modeling were both performed to estimate macromolecular fraction (MMF), and results with and without fat suppression were compared.

resultsFat-selective images revealed off-resonance artifacts from surrounding fatty tissues that extended into adjacent joint structures. Subtraction of the fat-selective images effectively suppressed these artifacts and improved visualization of cartilage, meniscus, and tendons. In ex vivo data, fat suppression stabilized MMF estimates by correcting voxels with abnormally elevated values (> 50%). MMF values were increased after fat suppression in articular cartilage (11.9 ± 1.3% vs. 17.3 ± 1.5%), meniscus (15.9 ± 0.8% vs. 18.2 ± 1.9%), patellar cartilage (13.5 ± 1.0% vs. 18.3 ± 0.4%), and patellar tendon (17.4 ± 2.8% vs. 24.6 ± 0.4%). Tissue contrast-to-noise ratios were also markedly improved. DISCUSSION: Subtraction of fat-selective images provides a simple and effective approach for suppressing fat interference in UTE-MT imaging, improving both image contrast and MT measurements.

Indexed as

Fat suppressionKnee MRIUTE

Identifiers

PMID42192057

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.