Evidence map›Paper›PMID 42192007›Full record

ArticleAesthetic plastic surgery2026

Unveiling Upper-Limb Dysfunction Early After Implant-Based Breast Reconstruction: Insights from a Retrospective Cohort Study.

Elisa Andrenelli, Matteo Torresetti, Enrico Lenti, Ilias Vurliotis, Ortensia Pirro, Maria Gabriella Ceravolo, Giovanni Di Benedetto, Marianna Capecci

Abstract readComparative Study
In one paragraph

Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elisa Andrenelli *Department of Experimental and Clinical Medicine, Neurorehabilitation Clinic, Marche Polytechnic University Medical School, Ancona, Italy.
Matteo Torresetti *Clinic of Plastic and Reconstructive Surgery, Department of Experimental and Clinical Medicine, Marche Polytechnic University Medical School, Ancona, Italy. m.torresetti@staff.univpm.it.ORCID http://orcid.org/0000-0003-3926-8584
Enrico LentiBreast Surgery Unit, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Ilias VurliotisDepartment of Experimental and Clinical Medicine, Neurorehabilitation Clinic, Marche Polytechnic University Medical School, Ancona, Italy.
Ortensia PirroClinic of Plastic and Reconstructive Surgery, Department of Experimental and Clinical Medicine, Marche Polytechnic University Medical School, Ancona, Italy.
Maria Gabriella CeravoloDepartment of Experimental and Clinical Medicine, Neurorehabilitation Clinic, Marche Polytechnic University Medical School, Ancona, Italy.
Giovanni Di BenedettoClinic of Plastic and Reconstructive Surgery, Department of Experimental and Clinical Medicine, Marche Polytechnic University Medical School, Ancona, Italy.
Marianna CapecciDepartment of Experimental and Clinical Medicine, Neurorehabilitation Clinic, Marche Polytechnic University Medical School, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrepectoral (PP) breast reconstruction has emerged as a muscle-sparing alternative to the subpectoral (SP) approach. While aesthetic and oncologic outcomes have been well studied, early functional recovery remains less explored.

methodsThis retrospective study assessed upper-limb function in women who underwent implant-based breast reconstruction, comparing direct-to-implant PP and two-stage SP approaches. Outcomes at one month included Quick Disabilities of Arm, Shoulder e Hand (QuickDASH) questionnaire, shoulder range of motion (ROM), International Physical Activity Questionnaire (IPAQ), and Body Image Scale. An exploratory analysis within the PP cohort compared outcomes according to implant coverage materials: acellular dermal matrix (ADM), synthetic mesh, and polyurethane-coated (PU).

resultsAmong 124 patients, 63 underwent PP and 61 SP reconstruction. PP patients reported lower disability (QuickDASH), better body image, and a lower prevalence of pathological shoulder ROM, particularly in internal rotation and flexion. Functional complications, including adherent scars, dysesthesia, lymphosclerosis, implant hypomobility, and pain, were less frequent in the PP group. Furthermore, fewer PP patients required postoperative rehabilitation. In multivariable analysis, only previous upper-limb dysfunction remained independently associated with higher QuickDASH scores. Within the PP group, ADM-and mesh-based reconstructions were associated with more favorable outcomes than PU implants and remained associated with lower disability after adjustment.

conclusionEarly postoperative upper-limb function following implant-based reconstruction is influenced by both reconstructive approach and patient-related factors, e.g., preexisting upper-limb dysfunction. Muscle-sparing strategies may support a more favorable functional outcome in the short term, though this hypothesis must be interpreted cautiously given the retrospective design of our study. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

Indexed as

Breast ImplantationBreast ImplantsBreast NeoplasmsMammaplastyUpper ExtremityAdultCohort StudiesDisability EvaluationEstheticsFemaleFollow-Up StudiesHumansMastectomyMiddle AgedPostoperative ComplicationsRange of Motion, ArticularAcellular dermal matrixFunctional outcomesMeshPolyurethane implantPrepectoral breast reconstructionUpper-limb function

Identifiers

PMID42192007
PMCPMC13433640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.