Evidence map›Paper›PMID 42191968›Full record

ArticleCell death and differentiation2026

Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence.

Markus S Hess, Kamal M Al-Shami, Carolina Dehesa Caballero, Julie Haenlin, Adriano B Chaves-Filho, Lisa Schlicker, Philipp Poeller, Felix C E Vogel, Ioanna Koltsaki, Deniz Gedik and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Markus S Hess *Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kamal M Al-Shami *Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carolina Dehesa CaballeroDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Julie HaenlinDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Adriano B Chaves-FilhoDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lisa SchlickerDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8350-2289
Philipp PoellerDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3924-5756
Felix C E VogelDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4067-2074
Ioanna KoltsakiDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Deniz GedikDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0009-0000-5412-9449
Marta Campos AlonsoDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0009-0008-7356-6095
Susanne WalzComprehensive Cancer Center Mainfranken, Würzburg, Germany.
Carsten P AdeBiochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, Würzburg, Germany.ORCID http://orcid.org/0000-0001-7226-1179
Martin EilersBiochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, Würzburg, Germany.ORCID http://orcid.org/0000-0002-0376-6533
Beate K StraubInstitute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Jochen S UtikalSkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Svenja MeierjohannInstitute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.
Mathias T RosenfeldtInstitute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.
Marteinn T SnaebjornssonDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0009-0008-4457-5726
Almut SchulzeDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. Almut.schulze@dkfz-heidelberg.de.ORCID http://orcid.org/0000-0002-8199-6422

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) DIPDeutsche Forschungsgemeinschaft (German Research Foundation) SCHU2670-2Deutsche Forschungsgemeinschaft (German Research Foundation) SPP2306
6 · The paper itself

Abstract

Oncogene-induced senescence (OIS), a cellular programme initiated by activation of oncogenic signalling, provides a barrier to transformation and is accompanied by major reprogramming of cellular metabolism. We show here that induction of OIS by BRAF

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.