Evidence map›Paper›PMID 42191945›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

The FAP-FDG Integration Score (FFIS): Development and prognostic validation of a dual-tracer PET phenotype for solid tumors.

Ya Liu, Ting Zhang, Jingwei Deng, Chang Yu, Tingting Xu, Lixian Mou, Haoyuan Ding, Yue Chen

Abstract readValidation Study
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ya Liu *Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China.
Ting Zhang *Department of General Practice, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China.
Jingwei Deng *Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China.
Chang YuDepartment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China.
Tingting XuDepartment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China.
Lixian MouDepartment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China. moulixian@163.com.
Haoyuan DingDepartment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China. 315699969@qq.com.
Yue ChenDepartment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, PR China. chenyue5523@126.com.ORCID 0000-0003-4088-7649

Funding

Gansu Provincial Science and Technology Major Project 23ZDFA014National Key Research and Development Program (NKRDP) Project 2024YFC2419405Sichuan Provincial Department of Science and Technology 2024YFCY0005
6 · The paper itself

Abstract

purposeTo develop a FAP-FDG integrated score (FFIS) based on [

methodsThis retrospective study included 193 patients with solid tumors who underwent both [

resultsFFIS emerged as an independent predictor of OS in both univariate (HR = 1.79, P < 0.001) and multivariate (HR = 1.75, P < 0.001) analyses. A higher FFIS reliably predicted worse survival: no deaths occurred among patients of score 1, whereas the median OS was 36, 13, and 8 months for scores 2, 3, and 4, respectively (Log-Rank P < 0.0001). This prognostic stratification remained consistent nearly all clinical subgroups (P-interaction > 0.05). In contrast, FDG-SUVmax showed no independent prognostic value, and FAP-SUVmax was predictive only in univariate analysis (HR = 1.04, P = 0.03).

conclusionBy integrating metabolic and stromal information, the FFIS may offer preliminary prognostic value across solid tumors.

Indexed as

Fluorodeoxyglucose F18NeoplasmsPositron Emission Tomography Computed TomographyAdultAgedFemaleFibroblast Activation Protein AlphaHumansMaleMiddle AgedPhenotypePrognosisRadiopharmaceuticalsRetrospective StudiesFibroblast Activation Protein AlphaFluorodeoxyglucose F18Radiopharmaceuticals[18F]F-FDG[68Ga]Ga-FAP-2286Solid tumorsSurvival analysis

Identifiers

PMID42191945

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