Evidence map›Paper›PMID 42191915›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

Comparison of neuromelanin-sensitive magnetic resonance imaging using different magnetic resonance protocols on the same patients with Parkinson's disease.

Rinka Hirose, Keita Matsuura, Yuichiro Ii, Hiroyuki Kajikawa, Masayuki Maeda, Maki Umino, Ken-Ichi Tabei, Akisato Nishigaki, Shotaro Horie, Hidehiro Ishikawa and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rinka HiroseSchool of Medicine, Mie University, Mie, 514-8507, Japan.
Keita MatsuuraDepartment of Neurology, Graduate School of Medicine, Mie University, Mie, 514-8507, Japan. kmatsuura@med.mie-u.ac.jp.
Yuichiro IiDepartment of Neuroradiology, Mie University School of Medicine, Tsu, Mie, 514-8507, Japan.
Hiroyuki KajikawaDepartment of Neurology, Graduate School of Medicine, Mie University, Mie, 514-8507, Japan.
Masayuki MaedaDepartment of Radiology, Suzuka Kaisei Hospital, Mie, 513-0836, Japan.
Maki UminoDepartment of Radiology, Graduate School of Medicine, Mie University, Mie, 514-8507, Japan.
Ken-Ichi TabeiSchool of Industrial Technology, Advanced Institute of Industrial Technology, Tokyo Metropolitan Public University Corporation, Tokyo, 192-0397, Japan.
Akisato NishigakiDepartment of Neurology, Graduate School of Medicine, Mie University, Mie, 514-8507, Japan.
Shotaro HorieDepartment of Neurology, Graduate School of Medicine, Mie University, Mie, 514-8507, Japan.
Hidehiro IshikawaDepartment of Neurology, Graduate School of Medicine, Mie University, Mie, 514-8507, Japan.
Ken KagawaDepartment of Neurology, Suzuka Kaisei Hospital, Mie, 513-0836, Japan.
Akihiro ShindoSchool of Medicine, Mie University, Mie, 514-8507, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and diagnostic significance of the contrast ratio (SN-CR) and area (SN-A), as well as their association with clinical symptoms. However, no reports have evaluated the consistency of NMIs acquired using different MR protocols in the same patients over a short period. Therefore, this study evaluated the similarity of two-dimensional (2D) NMIs obtained simultaneously under different imaging parameters. The SN-CR, LC-CR, and SN-A were compared in 54 of 55 patients with PD who underwent 2D NMIs within 3 months under different imaging conditions, with one patient excluded due to artifacts. The relationships of these variables with motor and cognitive function were then examined. The mean age of the cohort was 62.3 ± 8.0 years. The mean disease duration was 11.4 ± 5.2 years, and the male-to-female ratio was 25:29. No significant correlation was found for SN-CR (r = 0.233, p = 0.091) and LC-CR (ρ = 0.180, p = 0.192). However, a significant, albeit weak, positive correlation was observed for SN-A (ρ = 0.403, p = 0.003). Standardization of imaging protocols is essential to minimize technical variability.

Indexed as

Locus CoeruleusMagnetic Resonance ImagingMelaninsParkinson DiseaseSubstantia NigraAgedFemaleHumansMaleMiddle AgedMelaninsneuromelaninLocus coeruleusNeuromelanin-sensitive MRIParkinson’s diseaseProtocol standardizationReliabilitySubstantia nigra

Identifiers

PMID42191915
PMCPMC13687396

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.