Evidence map›Paper›PMID 42191895›Full record

ArticleNature cell biology2026

Epigenetic programming by H3K23ac defines lineage fate of Meg3

Ni Wei, Huiwen Zhan, Yujun Deng, Min Liu, Yao Xiao, Yanqiu Gong, Xiaodong Wang, Pengbo Guan, Xiaoxian Lou, Yusi Xie and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ni Wei *Center for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Huiwen Zhan *Center for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yujun Deng *Center for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Min Liu *Center for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yao Xiao *Center for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yanqiu GongCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Xiaodong WangCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Pengbo GuanCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Xiaoxian LouCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yusi XieCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yuemeng WangCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Zhonghan LiSchool of Life Science, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-5752-3417
Lunzhi DaiCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. lunzhi.dai@scu.edu.cn.ORCID http://orcid.org/0000-0002-3003-8910
Hongbo HuCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. hongbohu@scu.edu.cn.ORCID http://orcid.org/0000-0002-8177-7641
Huiyuan ZhangCenter for Immunology and Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. hyzhang@scu.edu.cn.ORCID http://orcid.org/0000-0002-1532-2462

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82025002,32230036,92574203National Natural Science Foundation of China (National Science Foundation of China) 82394411;82170113
6 · The paper itself

Abstract

Haematopoietic stem cells (HSCs) produce all blood and immune cells throughout life, but ageing progressively impairs their function, generating excessive myeloid and megakaryocyte cells at the expense of lymphocytes. This lineage imbalance contributes to immune decline, chronic inflammation and increased disease susceptibility in the elderly, yet the underlying mechanisms remain poorly understood. Here we show that a specific Meg3

Indexed as

AgingCell LineageCellular SenescenceEpigenesis, GeneticHematopoietic Stem CellsHistonesAnimalsCell DifferentiationHumansInflammationMegakaryocytesMiceMice, Inbred C57BLMyeloid CellsProto-Oncogene ProteinsProto-Oncogene Protein Spi-1HistonesProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-Activators

Identifiers

PMID42191895
PMCPMC13279281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.