ArticleCommunications biology2026
Juvenile hormone-mediated chromatin remodelling by cumulative action of downstream transcription factors, Hairy and Krüppel homolog 1.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Insect-specific juvenile hormone (JH) controls mosquito post-eclosion (PE) development, a stage crucial for subsequent blood meal-driven egg maturation. During PE, JH functions through the independent or cumulative actions of repressors Hairy and Krüppel homolog 1 (Kr-h1), initiating the downregulation of different target gene cohorts. A key factor governing candidate gene expression is its chromatin state, determined by the tightness of DNA wrapping around associated proteins. Chromatin remodeling alters DNA accessibility and impacts gene expression. Despite advances in our understanding of the JH signaling pathway, little is known about JH/Met-induced chromatin remodeling during gene repression. Using the Dengue mosquito Aedes aegypti, we show that repressors Hairy and Kr-h1 induce alternative chromatin modifications to repress their target genes. While Hairy causes widespread histone H4 deacetylation of target genes, Kr-h1 induces histone H3K9 trimethylation and chromatin compaction. For the candidate genes co-repressed by both Hairy and Kr-h1, the two factors have a cumulative effect on the chromatin modification of the target gene loci, downregulating their expression. Our findings shed light on the mechanism behind the cumulative action of transcriptional repressors Hairy and Kr-h1 involved in JH signal transduction.
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