Evidence map›Paper›PMID 42191876›Full record

ArticleDiabetologia2026

Clinical and psychological phenotypes of type 1 diabetes and disordered eating derived from a case vignette series: T1DE phenotypes.

Divina Pillay, Nadine Paul, Amy Harrison, Natalie Zaremba, Jennie Brown, Emmanouela Konstantara, Pil Lindgreen, Jacqueline Allan, Diane Turner, Miranda Rosenthal and 3 more

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Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Divina Pillay *Department of Psychological Medicine, Diabetes, Psychology and Psychiatry Research Group, King's College London, London, UK.
Nadine Paul *Department of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0001-8894-7271
Amy HarrisonDepartment of Psychological Medicine, Diabetes, Psychology and Psychiatry Research Group, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3771-9735
Natalie ZarembaDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1720-1621
Jennie BrownDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Emmanouela KonstantaraDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7205-285X
Pil LindgreenSteno Diabetes Center Copenhagen, Department of Prevention, Health Promotion, and Community Care, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4400-5498
Jacqueline AllanDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Diane TurnerDiabetes Centre, King's College Hospital, London, UK.
Miranda RosenthalDiabetes Centre, King's College Hospital, London, UK.
Janet TreasureInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0871-4596
Khalida IsmailDepartment of Psychological Medicine, Diabetes, Psychology and Psychiatry Research Group, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6084-449X
Marietta StadlerDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK. marietta.stadler@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6869-9960

Funding

KCH-KMRT JRC PhD studentshipNational Institute for Health Research (NIHR) CS-2017-17-023
6 · The paper itself

Abstract

aims/hypothesisType 1 diabetes and disordered eating (T1DE) is a common, complex comorbidity of type 1 diabetes with high morbidity and mortality risk. T1DE currently lacks a clear definition, diagnostic differentiation into phenotypes and clinical severity grading, which results in exclusion of people with T1DE from accessing appropriate treatments to improve outcomes.

methodsWe developed anonymised T1DE case vignettes from the baseline assessments of the Safe management of people with Type 1 diabetes and EAting Disorders studY (STEADY) and the London-T1DE pilot service at King's College Hospital for people with diabetes and severe eating disorder, integrating detailed biomedical and psychiatric data. In an iterative process, phenotypes of T1DE were developed, the T1DE vignettes were sorted into the different phenotypes and a clinical severity grading framework was developed.

resultsThe 70 participants (94.3% women) were 34.5 ± 10.6 years old with a diabetes duration of 18.4 ± 12.5 years and HbA CONCLUSIONS/

interpretationThe three T1DE phenotypes will serve as a basis for more precise clinical diagnosis and severity grading and will be used to develop future diagnostic screening tools, improved psychological interventions and integrated treatment care pathways to match the individual clinical presentation and severity in a personalised medicine approach.

Indexed as

Diabetes Mellitus, Type 1Feeding and Eating DisordersAdultFemaleHumansMaleMiddle AgedPhenotypeYoung AdultDisordered eatingEating disorderMental healthType 1 diabetes

Identifiers

PMID42191876
PMCPMC13310201

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