Observational studyInternational journal of obesity (2005)2026
Unmasking the role of hypertension in atherosclerosis among patients with obesity: a cardiometabolic dysfunction perspective.
Observational study in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04040777 (Cardiometabolic Risk Factors Registry), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiometabolic Risk Factors Registry
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesVascular alterations in obesity may arise primarily from associated metabolic and inflammatory disturbances rather than from excess adiposity per se. This study evaluated the relative strength of association of individual BioSHaRE-EU Healthy Obese Project-defined cardiometabolic abnormalities and low-grade inflammation with carotid-iliofemoral subclinical atherosclerosis in adults with obesity. SUBJECTS/
methodsIn this cross-sectional analysis from the CARFARE registry (NCT04040777), asymptomatic adults with obesity (BMI ≥ 30 kg/m²) underwent standardized clinical evaluation and carotid-iliofemoral ultrasonography. Atherosclerosis was defined by the presence of ≥1 plaque according to Mannheim criteria. Metabolic status was classified as metabolically healthy or unhealthy obesity, with individual evaluation of hypertension, elevated fasting glucose, hypertriglyceridemia, and low HDL cholesterol. Inflammation was estimated through absolute neutrophil count. Associations were assessed using multivariable logistic regression adjusted for established cardiovascular risk factors. Sensitivity analyses included parsimonious models focused on hypertension and cardiovascular risk factors, and restriction of assessment to Mannheim-defined carotid territories.
resultsAmong 2033 participants, overall atherosclerosis prevalence was 56.5% (95% CI 54.3-58.7%), higher in metabolically unhealthy than healthy obesity (64.5% vs. 35.5%, p < 0.0001). In multivariable analysis, hypertension (OR 1.88, 95% CI 1.44-2.44, p < 0.0001) and low HDL cholesterol (OR 1.33, 95% CI 1.04-1.69, p = 0.0225) were independently associated with subclinical atherosclerosis, along with age, male sex, and smoking. In the parsimonious clinically oriented model, hypertension remained independently associated with subclinical atherosclerosis (adjusted OR 1.97, 95% CI 1.52-2.53; p < 0.001), with effect estimates comparable to the primary analysis. The magnitude and direction of the association were consistent across primary, parsimonious, and Mannheim-restricted analyses.
conclusionsIn individuals with obesity, hypertension showed the largest effect estimate for association with subclinical atherosclerosis among evaluated cardiometabolic abnormalities and low-grade inflammation. These findings suggest that blood pressure elevation may represent a clinically informative indicator of vascular vulnerability in obesity, without implying a causal relationship. Graphical Abstract.
Indexed as
Identifiers
42191873What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.