Evidence map›Paper›PMID 42191863›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Persistent vulnerability to heroin relapse after more than one year of abstinence in rats.

Rajtarun Madangopal, Olivia R Drake, Diana Q Pham, Veronica A Lennon, Sophia J Weber, Justine Lee, Adekemi Sobukunola, Ava R Holmes, Omodolapo Nurudeen, Yavin Shaham and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rajtarun MadangopalBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. rajtarun.madangopal@nih.gov.ORCID http://orcid.org/0000-0001-6202-302X
Olivia R DrakeBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Diana Q PhamBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Veronica A LennonBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Sophia J WeberBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-0845-7385
Justine LeeBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Adekemi SobukunolaBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Ava R HolmesBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Omodolapo NurudeenBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Yavin Shaham *Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Bruce T Hope *Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5804-7061

Funding

U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA000434U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA000467
6 · The paper itself

Abstract

Relapse to opioid use during abstinence is often triggered by drug-associated cues but the persistence of this effect during prolonged abstinence is unknown. Using a rat model, we found that relapse provoked by heroin-predictive discriminative stimuli persisted for over one year of abstinence, suggesting enduring, potentially lifelong opioid relapse vulnerability.

Indexed as

HeroinHeroin DependenceAnimalsCuesMaleRatsRats, Sprague-DawleyRecurrenceTime FactorsHeroin

Identifiers

PMID42191863
PMCPMC13291333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.