ArticleScientific reports2026
H. pylori-induced hsa_circ_0085465 promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-33b-3p.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a type of non-coding RNA molecule whose functional processes in carcinogenesis and progression are not fully known. Recent studies suggest that circRNAs can act as functional RNAs involved in the progression of various tumors. This study aims to investigate the role of hsa_circ_0085465 in the proliferation, migration, and invasion processes of gastric cancer cells. By establishing models of Helicobacter pylori (H. pylori)-infected normal gastric epithelial cells and gastric cancer cells, we conducted whole transcriptome sequencing and bioinformatics analysis, which led to the identification of a significantly upregulated circular RNA molecule, hsa_circ_0085465. Subsequently, we investigated the function of hsa_circ_0085465 in gastric cancer through in vitro functional experiments, including scratch wound healing assays and transwell assays, as well as in vivo animal experiments. Then, the downstream target miRNA of hsa_circ_0085465 were identified using sequencing and bioinformatics analysis, and the binding between hsa_circ_0085465 and the target gene miR-33b-3p was validated using dual-luciferase reporter gene assays and fluorescence in situ hybridization (FISH). Finally, we explored the interaction between hsa_circ_0085465 and miR-33b-3p through in vitro functional analyses. In a gastric cell model infected with H. pylori, the expression level of hsa_circ_0085465 was significantly upregulated. In vitro experiments demonstrated that hsa_circ_0085465 promotes the proliferation, migration, and invasion of gastric cancer cells, while in vivo subcutaneous tumor model further confirmed that hsa_circ_0085465 markedly accelerates tumor growth. Subsequent analyses identified miR-33b-3p as a downstream target of hsa_circ_0085465, and miR-33b-3p was found to suppress the proliferation, migration, and invasion of gastric cancer cells. Rescue experiments further demonstrated that miR-33b-3p can partially reverse the oncogenic effects of hsa_circ_0085465 in gastric cancer. H. pylori induced the upregulation of hsa_circ_0085465 in gastric cells, and hsa_circ_0085465 functions as a molecular sponge for miR-33b-3p, thereby promoting the proliferation, migration, and invasion of gastric cancer cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.