Emerging quality-by-design optimized HPLC method for the concurrent determination of cefixime and ornidazole: a multi-criteria green and blue environmental footprinting.

Yasmeen E Mostafa, Fawzi Elsebaei, Mohammed El-Sayed Metwally

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Yasmeen E MostafaDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, P.O. Box 35516, Mansoura, Egypt. yasmeenesmail86@mans.edu.eg.

Fawzi ElsebaeiDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, P.O. Box 35516, Mansoura, Egypt.

Mohammed El-Sayed MetwallyDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, P.O. Box 35516, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Design of experiments has emerged as an influential and proactive approach that demonstrated favored applicability in optimizing chromatographic procedures. Quality-by-design guarantees the long-standing efficiency of the developed HPLC method reducing the need for costly and resource-intensive univariate approach. A low environmental footprint, sensitive, fast, and simple HPLC method was developed for concurrent estimation of cefixime (CFX) and ornidazole (ORN) in their raw materials, laboratory-prepared tablets, and pharmaceutical formulations using 2

Indexed as

Anti-Bacterial AgentsCefiximeOrnidazoleChromatography, High Pressure LiquidReproducibility of ResultsTabletsAnti-Bacterial AgentsCefiximeOrnidazoleTabletsCefiximeFull factorial designHPLCLaboratory prepared tabletOrnidazoleSustainability profile

Identifiers

PMID42191742

DOI10.1038/s41598-026-51859-3

PMCPMC13212902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.