Evidence map›Paper›PMID 42191729›Full record

ArticleNature communications2026

Gene-in-gene coding generates dual-isoform Fha condensates to control type VI secretion system assembly.

Tong-Tong Pei, Qiao-Yu Chen, Xing-Yu Wang, Amy Ma, Jia-Xin Liang, Zi-Yan Ye, Yu-Zhao Liu, Jing-Tong Su, Xiaoye Liang, Ying An and 2 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tong-Tong PeiDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0004-8241-8896
Qiao-Yu ChenDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Xing-Yu WangDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Amy MaDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2311-6965
Jia-Xin LiangDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Zi-Yan YeDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yu-Zhao LiuDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0008-1095-5472
Jing-Tong SuDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Xiaoye LiangDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Ying AnDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jun ZhuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9182-5224
Tao DongDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China. dongt@sustech.edu.cn.ORCID http://orcid.org/0000-0003-3557-1850

Funding

China Postdoctoral Science Foundation 2025M782655China Postdoctoral Science Foundation GZC20251798Guangdong Innovative and Entrepreneurial Research Team Program 2023ZT10Y013National Natural Science Foundation of China (National Science Foundation of China) 32400096National Natural Science Foundation of China (National Science Foundation of China) 32500088National Natural Science Foundation of China (National Science Foundation of China) 32530004National Natural Science Foundation of China (National Science Foundation of China) W2431022National Natural Science Foundation of China (National Science Foundation of China) W2433062
6 · The paper itself

Abstract

While eukaryotes employ alternative splicing to diversify protein functions, analogous strategies in bacteria remain underexplored. Here we identify a conserved intragenic coding mechanism in Vibrio cholerae that generates two isoforms of the essential scaffold Fha and show that these isoforms cooperate through liquid-liquid phase separation to promote the assembly of the type VI secretion system (T6SS). The full-length isoform, Fha

Indexed as

Bacterial ProteinsType VI Secretion SystemsVibrio choleraeAmino Acid SequencePhase SeparationProtein IsoformsBacterial ProteinsProtein IsoformsType VI Secretion Systems

Identifiers

PMID42191729
PMCPMC13389060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.