Evidence map›Paper›PMID 42191725›Full record

ArticleNature communications2026

qChIP-MS reveals the local chromatin composition by label-free quantitative proteomics.

Wai Khang Yong, Nurkaiyisah Zaal Anuar, Zi Wayne Sin, Elayne Su Ru Tan, Grishma Rane, Xiaoman Shao, Chai Yeen Goh, Vartika Khanchandani, Vivian L S Kuan, Peh Fern Ong and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wai Khang YongCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0003-0872-9085
Nurkaiyisah Zaal AnuarCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0009-0007-7103-6907
Zi Wayne SinCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0009-0008-2255-1600
Elayne Su Ru TanCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Grishma RaneCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Xiaoman ShaoCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3285-1892
Chai Yeen GohCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Vartika KhanchandaniCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-9331-3051
Vivian L S KuanCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Peh Fern OngCell Aging Laboratory, A*STAR Skin Research Labs, Singapore, Singapore.
Maya JeitanySchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
H Phillip KoefflerCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5839-9913
Lih-Wen DengIntegrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4985-7844
Oliver DreesenCell Aging Laboratory, A*STAR Skin Research Labs, Singapore, Singapore.ORCID http://orcid.org/0000-0003-1148-3557
Takaomi SandaCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0003-1621-4954
Dennis KappeiCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. dennis.kappei@nus.edu.sg.ORCID http://orcid.org/0000-0002-3582-2253

Funding

MOH | National Medical Research Council (NMRC) MOH-OFIRG21jun-011National University of Singapore (NUS) NUSMED/2020/PDF/02
6 · The paper itself

Abstract

Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately limited to one protein at a time. In a complementary effort, we here combine ChIP with label-free quantitative mass spectrometry (qChIP-MS) to interrogate local chromatin compositions. We demonstrate the versatility of our approach at telomeres, with transcription factors, in tissue and by dCas9-mediated locus-specific enrichment.

Indexed as

ChromatinMass SpectrometryProteomicsAnimalsChromatin ImmunoprecipitationChromatin Immunoprecipitation SequencingHumansMiceTelomereTranscription FactorsChromatinTranscription Factors

Identifiers

PMID42191725
PMCPMC13389084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.