Evidence map›Paper›PMID 42191205›Full record

ArticleBMJ open2026

Does a protocolised oxygenation target impact clinical outcomes in mechanically ventilated patients in the intensive care unit across the 10 academic and community hospitals in the UCHealth system? Protocol and statistical analysis plan for an EHR-embedded pragmatic stepped-wedge randomised controlled trial.

Peter D Sottile, Mark E Mikkelsen, Ryan A Peterson, Max Mcgrath, Nichole Carlson, Carrie Higgins, Margaret I Clinton, Aaron Barbour, Sarah V Kautz, Bethany M Kwan and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06501118 (Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06501118 narecruitingnot on this map

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

TypeinterventionalSponsorUniversity of Colorado, DenverRan2024 to 2026Enrolled3,600ConditionsRespiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, HypoxemiaArmsEducation, Epic notification alert
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peter D SottileDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA peter.sottile@cuanschutz.edu.ORCID http://orcid.org/0000-0002-1071-730X
Mark E MikkelsenDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Ryan A PetersonDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Max McgrathDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado, USA.
Nichole CarlsonDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado, USA.
Carrie HigginsDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Margaret I ClintonDepartment of Emergency Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Aaron BarbourDepartment of Emergency Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Sarah V KautzColorado Clinical Translational Sciences Institute, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Bethany M KwanDepartment of Emergency Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Shelby WestDepartment of Emergency Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Adit A GindeDepartment of Emergency Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.
Neil AggarwalDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado | Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe designed the Optimising Care in Critically Ill at the UCHealth by Liberalising the Target O₂ in Mechanically ventilated intensive care unit (ICU) Patients to determine the effectiveness of a multimodal educational and electronic health record order panel intervention in limiting occult hypoxaemia and hyperoxaemia in patients receiving invasive mechanical ventilation by targeting a prespecified oxygen saturation (S METHODS AND ANALYSIS: This trial is a pragmatic electronic health record-embedded, multisite, cluster-randomised, stepped-wedge implementation of a multimodal educational and electronic health record order panel intervention aimed at achieving a standardised intermediate target range of S ETHICS AND DISSEMINATION: Research is performed under a waiver of informed consent for minimal-risk research, as approved by Colorado Multiple Institutional Review Board (24-0065). Results will be disseminated in peer-reviewed publications and at national and international conferences. TRIAL REGISTRATION NUMBER: NCT06501118.

Indexed as

HyperoxiaHypoxiaIntensive Care UnitsOxygenRespiration, ArtificialCritical IllnessElectronic Health RecordsHospitals, CommunityHumansMulticenter Studies as TopicOxygen SaturationPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicResearch DesignOxygenElectronic Health RecordsHypoxiaPragmatic Clinical TrialVentilators, Mechanical

Identifiers

PMID42191205
PMCPMC13218103

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.