Evidence map›Paper›PMID 42190867›Full record

ArticleThe Journal of investigative dermatology2026

Hmga2-dependent cAMP signaling drives UVB-induced melanocyte stem cell activation.

Leanne R Donahue, Chia-Hsin Hsu, Youngeun H Yang, Alex Wong, Luye An, Dahihm Kim, Andrew C White

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leanne R DonahueDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA.
Chia-Hsin HsuDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA.
Youngeun H YangDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA.
Alex WongDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA.
Luye AnDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA.
Dahihm KimDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA.
Andrew C WhiteDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, New York, USA. Electronic address: acw93@cornell.edu.

Funding

Regulators of Melanocyte Stem Cell Migration and Melanoma Initiation in Response to Cutaneous UVB IrradiationR01AR075755 · NIAMS · CORNELL UNIVERSITY · PI WHITE, ANDREW C · 2020 to 2024
$1.5M
Regulators of Melanocyte Stem Cell Migration and Melanoma Initiation in Response to Cutaneous UVB IrradiationR56AR075755 · NIAMS · CORNELL UNIVERSITY · PI WHITE, ANDREW C · 2019 to 2019
$332k
NIAMS NIH HHS R01 AR075755NIAMS NIH HHS R56 AR075755
6 · The paper itself

Abstract

UVB induces an epidermal damage response, including keratinocyte hyperplasia, immune cell infiltration, and the recruitment of follicular melanocyte stem cells to the interfollicular epidermis. In this study, we establish the oncofetal chromatin remodeling factor Hmga2 (high mobility group AT-hook 2) as a regulator of these phenotypes through a cAMP-driven process. In this study, we identify somatic tissue expression of Hmga2 in the basal layer of hyperplastic UVB-exposed keratinocytes. Loss of Hmga2 results in the near absence of epidermal hyperplasia, cutaneous neutrophil infiltration, and melanocyte stem cell migration to the interfollicular epidermis. RNA sequencing of UVB-exposed keratinocytes from wild-type and Hmga2 loss-of-function models reveals increased expression of Adora1 (adenosine A1 receptor), a negative regulator of cAMP. Administration of the cAMP pathway activator forskolin to Hmga2

Indexed as

Cyclic AMPHMGA2 ProteinMelanocytesStem CellsUltraviolet RaysAnimalsCell MovementCells, CulturedEpidermisHumansKeratinocytesMiceMice, KnockoutSignal TransductionCyclic AMPHMGA2 ProteinCell migrationMouse modelsUVR

Identifiers

PMID42190867
PMCPMC13546127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.