Evidence map›Paper›PMID 42190844›Full record

ArticleMagnetic resonance imaging2026

SNAP MRI reveals association between distal cerebral arterial flow and cognitive function in an aging population.

Xiaodong Ma, Vincent Koppelmans, Halit Akcicek, Ebru Yaman Akcicek, Jincheng Shen, Li Chen, Niranjan Balu, Chun Yuan, Jace B King

Abstract read
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In one paragraph

Article in Magnetic resonance imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiaodong MaDepartment of Radiology and Imaging Sciences, University of Utah, United States of America. Electronic address: xiaodong.ma@hsc.utah.edu.
Vincent KoppelmansDepartment of Psychiatry, University of Utah, United States of America.
Halit AkcicekDepartment of Radiology and Imaging Sciences, University of Utah, United States of America.
Ebru Yaman AkcicekDepartment of Radiology and Imaging Sciences, University of Utah, United States of America.
Jincheng ShenDepartment of Internal Medicine, University of Utah, United States of America.
Li ChenPhilips Research North America, United States of America.
Niranjan BaluDepartment of Radiology, University of Washington, United States of America.
Chun YuanDepartment of Radiology and Imaging Sciences, University of Utah, United States of America.
Jace B KingDepartment of Radiology and Imaging Sciences, University of Utah, United States of America.

Funding

Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeR01HL103609 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS, YUAN, CHUN · 2011 to 2021
$7.1M
Automated Intracranial Vessel Wall Analysis Pipeline for Multi-contrast Multi-platform ApplicationsR01NS127317 · NINDS · UNIVERSITY OF WASHINGTON · PI MOSSA-BASHA, MAHMUD, YUAN, CHUN · 2022 to 2025
$2.2M
Motor Profiles as Novel Biomarker for Alzheimer’s DiseaseK01AG073578 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KOPPELMANS, VINCENT · 2021 to 2025
$651k
Novel metrics of brain dynamics in Alzheimer’s diseaseK01AG075166 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jace Bradford King · 2022 to 2026
$651k
NHLBI NIH HHS R01 HL103609NIA NIH HHS K01 AG073578NIA NIH HHS K01 AG075166NINDS NIH HHS R01 NS127317
6 · The paper itself

Abstract

objectiveImpaired blood flow has recently been recognized as a critical contributor to cognitive impairment and dementia. It was reported that cerebral distal arterial flow measured from Simultaneous Non-contrast Angiography and Intraplaque Hemorrhage (SNAP) MRI is associated with post-treatment cognitive function improvement in carotid atherosclerosis patients. In this study, we aim to evaluate the value of SNAP-based measurements in assessing cerebrovascular function in an aging population. MATERIALS AND

methodsNeurovascular MRI data were collected on 36 aging participants (22 cognitively unimpaired and 14 impaired; 9 mild cognitive impairment (MCI) and 5 Alzheimer's Disease (AD)). Neurovascular MRI measurements, including white matter hyperintensities (WMH) volumes, cerebral blood flow (CBF), and SNAP-based distal cerebral arterial flow (dCAF) index, were quantified. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

resultsSignificant differences in the dCAF index were observed between cognitively unimpaired and impaired groups, and the dCAF index was significantly correlated with the RBANS total score. While CBF was significantly associated with dCAF index, there is no significant correlation of CBF or WMH with the RBANS score in this population.

conclusionOur findings suggest that the dCAF measured with SNAP MRI is valuable for evaluating the cognition-related cerebrovascular condition in an aging population.

Indexed as

AgingCerebral ArteriesCerebrovascular CirculationCognitionCognition DisordersCognitive DysfunctionMagnetic Resonance AngiographyMagnetic Resonance ImagingAgedAged, 80 and overBlood Flow VelocityFemaleHumansMaleNeuropsychological TestsReproducibility of ResultsAlzheimer's diseaseCognitive impairmentDistal cerebral arterial flowNeurovascular MRISNAP

Identifiers

PMID42190844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.