Evidence map›Paper›PMID 42190812›Full record

ArticleThe Journal of biological chemistry2026

HIF-1α drives distinct aspects of hypoxia-induced glucose metabolism in intestinal epithelial cells.

Sarah J Kierans, Ciarán Kennedy, Rory Turner, Darragh Flood, Emily DeMichele, Martina Wallace, Cormac T Taylor

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah J KieransUCD School of Medicine, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland.
Ciarán KennedyConway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland; UCD School of Biomolecular and Biomedical Science & UCD Diabetes Complications Research Centre, University College Dublin, Belfield, Dublin, Ireland.
Rory TurnerConway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland; UCD School of Agriculture and Food Science & UCD Diabetes Complications Research Centre, University College Dublin, Belfield, Dublin, Ireland.
Darragh FloodUCD School of Medicine, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland.
Emily DeMicheleUCD School of Medicine, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland.
Martina WallaceConway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland; UCD School of Agriculture and Food Science & UCD Diabetes Complications Research Centre, University College Dublin, Belfield, Dublin, Ireland.
Cormac T TaylorUCD School of Medicine, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland; Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland. Electronic address: cormac.taylor@ucd.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypoxia-inducible factor-1α (HIF-1α) has canonically been described as a primary regulator of glucose metabolism in hypoxic cells through transcriptional upregulation of all 10 glycolytic enzymes. Here, using

Indexed as

Epithelial CellsGlucoseHypoxia-Inducible Factor 1, alpha SubunitIntestinal MucosaAnimalsCell HypoxiaCitric Acid CycleGlutamineGlycolysisHumansMetabolic ReprogrammingGlucoseGlutamineHypoxia-Inducible Factor 1, alpha Subunitglucose metabolismglycolysisHIF-1hypoxiametabolomicsTCA cycle

Identifiers

PMID42190812
PMCPMC13314749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.