Evidence map›Paper›PMID 42190640›Full record

ArticleEBioMedicine2026

Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8

Susana Patricia Amaya Hernandez, Kamilla Kjærgaard Munk, Konstantin Danilov, Mohammad Kadivar, Ditte Stampe Hersby, Tripti Tamhane, Simone Majken Stegenborg-Grathwohl, Anders Gorm Pedersen, Anne Ortved Gang, Sine Reker Hadrup and 1 more

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Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susana Patricia Amaya HernandezDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Kamilla Kjærgaard MunkDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Konstantin DanilovDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Mohammad KadivarDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Ditte Stampe HersbyDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 2100, Denmark.
Tripti TamhaneDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Simone Majken Stegenborg-GrathwohlDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Anders Gorm PedersenDepartment of Health Technology, Section for Bioinformatics, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Anne Ortved GangDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 2100, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, 2200, Denmark.
Sine Reker HadrupDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Sunil Kumar SainiDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark. Electronic address: sukusa@dtu.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD8

methodsWe performed comprehensive longitudinal profiling of antigen-specific CD8

findingsSevere and mild COVID-19 were associated with robust yet distinct patterns of CD8

interpretationThese findings delineate the epitope-specific frequency, function, and persistence of antigen-specific T-cell populations during SARS-CoV-2 infection, highlighting how differential activation, rather than magnitude alone, shapes immune outcomes across disease severities and other viral infections.

fundingThis work was supported by the Independent Research Fund Denmark (DFF-Sapere Aude, 2066-00044B), the EU Horizon Europe REACT project (101057129), the European Research Council (ERC) Starting Grant MIMIC (101045517), and the Danish National Research Foundation (DNRF170).

Indexed as

CD8-Positive T-LymphocytesCOVID-19Epitopes, T-LymphocyteSARS-CoV-2AdultAgedCOVID-19 VaccinesCytokinesFemaleHumansImmunologic MemoryLongitudinal StudiesLymphocyte ActivationMaleMiddle AgedSeverity of Illness IndexCOVID-19 VaccinesCytokinesEpitopes, T-LymphocyteCD8(+) T-cellsCOVID-19COVID-19 vaccinationSARS-CoV-2T-cell epitopesT-cell memoryViral infections

Identifiers

PMID42190640
PMCPMC13234737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.