ArticleDermatology practical & conceptual2026
Clinical and Dermoscopic Characterization of Mixed-Type Basal Cell Carcinoma.
Article in Dermatology practical & conceptual, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionBasal cell carcinoma (BCC) is a malignant skin tumor that originates from epidermal basal cells or the outer root sheath of hair follicles. Identifying histopathological subtypes is crucial to guiding treatment and patient follow-up. While dermoscopic features associated with histopathological subtypes have been studied, the changes in dermoscopic findings in mixed-type BCC remain unclear.
objectivesThis study aimed to analyze the demographic characteristics of patients diagnosed with single and mixed-type BCC and to investigate the correlation between clinical and dermoscopic findings and histopathological subtypes.
resultsA total of 186 BCC lesions from 157 patients were analyzed. The mean patient age was 68.8±12.7 years (range: 30-94). The most common lesion location was the head and neck region (74.7%). The distribution of histopathological subtypes was as follows: nodular (42.5%), mixed-type (37.6%), superficial (12.4%), basosquamous (3.2%), infiltrative (2.7%), micronodular (1.1%), and fibroepithelial (0.5%). The most frequent mixed-type BCC combinations were nodular-infiltrative (32.9%), nodular-superficial (31.4%), and nodular-micronodular (12.9%).Short fine telangiectasia, yellow-white structureless areas, scales, and rosette structures were more frequent in mixed-type BCC. Corkscrew vessel patterns were more common in single-type lesions. The presence of a superficial component in mixed-type BCC was associated with wheel-like structures, while infiltrative components correlated with dotted and glomerular vessel patterns, and basosquamous components were linked to arborizing vessel patterns. Additionally, arborizing vessel patterns (P=0.019) and dotted vessel patterns (P=0.025) were associated with high-risk subtypes in mixed-type BCC.
conclusionOur study suggests that dermoscopic findings may serve as a guide to recognizing mixed-type BCC lesions, distinguishing between subtype components, and assisting in treatment decision-making based on these observations.
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