Evidence map›Paper›PMID 42190017›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Electrical stimulation promotes longevity and regeneration in a colonial chordate.

Jos Domen, Yotam Voskoboynik, Tom Levy, Erica M Domen, Katherine J Ishizuka, Karla J Palmeri, Chiara Anselmi, Thomas Rolander, Norma F Neff, Angela M Detweiler and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Electrical stimulation promotes longevity and regeneration in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jos Domen *Biology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Yotam VoskoboynikDepartment of Bioinformatics and System Biology, Jacobs School of Engineering, University of California, San Diego, CA 92093.
Tom LevyBiology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Erica M DomenDepartment of Integrative Biology, University of California, Berkeley, CA 94704.
Katherine J IshizukaBiology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Karla J PalmeriBiology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Chiara AnselmiBiology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Thomas RolanderBiology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Norma F NeffChan Zuckerberg Biohub SF, San Francisco CA 94158.ORCID 0000-0001-7141-5420
Angela M DetweilerChan Zuckerberg Biohub SF, San Francisco CA 94158.
Irving L Weissman *Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-9077-7467
Kimberly L Gandy *Biology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Debashis Sahoo *Department of Pediatrics, University of California, San Diego, CA 92093.
Ayelet Voskoboynik *Biology Department, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950.

Funding

NIH NIA 5RO1 AG076908
6 · The paper itself

Abstract

Endogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell-mediated repair is not well understood. We demonstrate that a brief, clinically safe pulse of electrical current (PEC) produces lasting rejuvenation in the colonial chordate

Indexed as

ChordataElectric StimulationLongevityRegenerationUrochordataAnimalsStem Cellslongevitypulsatile electrical currentrejuvenationstem cell agingtunicate

Identifiers

PMID42190017
PMCPMC13229227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.