Evidence map›Paper›PMID 42190016›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

HHIP's dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility.

Dávid Deritei, Wardatul Jannat Anamika, Anny Xiaobo Zhou, Jeong H Yun, Maor Sauler, Michael H Cho, Edwin K Silverman, Erzsébet Ravasz Regan, Kimberly Glass

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Dávid DeriteiChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-7584-4828
Wardatul Jannat AnamikaChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.
Anny Xiaobo ZhouChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.
Jeong H YunChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.
Maor SaulerPulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520-8057.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.
Edwin K Silverman *Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-3641-3822
Erzsébet Ravasz Regan *Biochemistry and Molecular Biology, Department of Biology, The College of Wooster, Wooster, OH 44691.ORCID 0000-0002-8663-3153
Kimberly Glass *Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.

Funding

Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SILVERMAN, EDWIN K · 2013 to 2025
$24.9M
COPD Susceptibility, Heterogeneity, and Progression: Proteomics and GeneticsR01HL133135 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORITZ, ROBERT L, SILVERMAN, EDWIN K · 2017 to 2025
$7.2M
Metabolic Control of Stemness in lung epithelial progenitors by FAM13AR01HL127200 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, ANNY XIAOBO · 2015 to 2024
$4.9M
Leveraging Variant-perturbed Gene Regulation to Support Precision Medicine in COPDR01HL155749 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Kimberly Renee Glass · 2022 to 2026
$4.2M
Identifying Protein-Protein Network Interactions between COPD Susceptibility GenesR01HL152728 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K, WEI, WENYI · 2021 to 2024
$3.2M
Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosisR01HL162813 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO · 2023 to 2026
$3.1M
Integrative genomic, transcriptomic and proteomic studies of pulmonary function and COPDR01HL153248 · NHLBI · UNIVERSITY OF VIRGINIA · PI CHO, MICHAEL H., MANICHAIKUL, ANI WANG · 2021 to 2024
$2.8M
Integrative Characterization on the function of COPD GWAS gene, HHIPR01HL148667 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEI, WENYI, ZHOU, ANNY XIAOBO · 2020 to 2023
$2.6M
Identifying Subtypes of COPD Using Metabolomic and Genomic ApproachesR01HL168199 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO · 2024 to 2026
$2.1M
The role of COPD genetic risk factor HHIP on lymphocytic inflammationK08HL146972 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI YUN, JEONG H · 2020 to 2024
$848k
NHLBI NIH HHS K08 HL146972NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL127200NHLBI NIH HHS R01 HL133135NHLBI NIH HHS R01 HL148667NHLBI NIH HHS R01 HL152728NHLBI NIH HHS R01 HL153248NHLBI NIH HHS R01 HL155749NHLBI NIH HHS R01 HL162813NHLBI NIH HHS R01 HL168199
6 · The paper itself

Abstract

Genetic variants near Hedgehog interacting protein (

Indexed as

Carrier ProteinsPulmonary Disease, Chronic ObstructiveWound HealingAnimalsEpithelial CellsEpithelial-Mesenchymal TransitionGenetic Predisposition to DiseaseHedgehog ProteinsHumansMembrane GlycoproteinsMiceSignal TransductionZinc Finger Protein GLI1Zinc Finger Protein Gli2Carrier ProteinsHedgehog ProteinsHHIP protein, humanMembrane GlycoproteinsZinc Finger Protein GLI1Zinc Finger Protein Gli2BooleanCOPDHHIPmechanismnetworks

Identifiers

PMID42190016
PMCPMC13225619

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.