Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed.
Polyploidy and stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
Article
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Alexandra L Purdy *Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.
Amirala Bakhshian Nik *Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0002-1176-1628
Anooj A ArkatkarDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0009-0007-9155-8526
Prottoy HasanDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0001-9968-3400
Michael A FlinnDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0002-8200-1693
Priyanka ChoudhuryDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.
Cheyret WoodCenter for Innovative Design and Analysis, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-9418-4917
Akiko TakizawaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
Lynn MalloyDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
Monika TutajDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0002-0378-4002
Thomas A DrysdaleChildren's Health Research Institute, Victoria Research Labs, London, ON N6A 4L6, Canada.ORCID 0000-0002-7254-2189
Darren BridgewaterDepartment of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
Brian A LinkDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0002-7173-2642
Timothy F PlagemanCollege of Optometry, The Ohio State University, Columbus, OH 43210.ORCID 0000-0001-6565-2577
Anne E KwitekDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0003-1024-4116
Melinda R DwinellDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
Laura M SabaDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Caitlin C O'MearaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
Michaela PattersonDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0002-3805-4181
Funding
Hybrid Rat Diversity Program - Import of HXB/BXH panelR24OD024617 · OD · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MELINDA R · 2018 to 2025
$6.8M
INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Genetic interactions and multifactorial genetics mediate myocardial regenerationR01HL155085 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PATTERSON, MICHAELA · 2021 to 2025
$2.5M
Modulators of cardiomyocyte structure to promote functional recovery during cardiac regeneration and repairR01HL170547 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Brian A Link, Caitlin C O'Meara · 2023 to 2026
$2.1M
Medical Scientist Training ProgramT32GM154638 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI Joseph T Barbieri, Nita H Salzman · 2025 to 2026
$1.8M
Genetic mapping of variable cardiac cell composition in the ratR21HL156022 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI O'MEARA, CAITLIN C, PATTERSON, MICHAELA · 2021 to 2022
$443k
American Heart Association (AHA) 24TPA1291588HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL155085HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL170547HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL64541HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R21HL156022HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL007852HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL134643HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM154638HHS | NIH | NIH Office of the Director (OD) R24OD024617MCW Cardiovascular Research Center pilot awardNHLBI NIH HHS R01 HL155085NHLBI NIH HHS R21 HL156022
6 · The paper itself
Abstract
Various states of cardiomyocyte (CM) polyploidy have been associated with cardiac injury responses, including regeneration and heart failure. However, our understanding of the comprehensive mechanisms governing CM ploidy and its relationship with heart physiology is limited. To address this issue and uncover genetic regulators, we surveyed CM ploidy across a new genetic resource known as the Hybrid Rat Diversity Panel (HRDP) and found significant variation in ploidy phenotypes across the panel. Using select rat strains with divergent displays of CM ploidy, we found that CM hyperpolyploidization (≥8 N) positively correlates with various physiological parameters, namely left ventricular dilation and reduced ejection fraction. Genome-wide association mapping identified several loci significantly associated with frequency of hyperpolyploid CMs. Investigation of genes harboring damaging protein coding variants within these loci identified enrichment of cytoarchitectural genes, of which the ACTIN-binding protein,
Indexed as
Genome-Wide Association StudyHeart VentriclesMicrofilament ProteinsMyocytes, CardiacPolyploidyAnimalsFemalePhenotypeRatsMicrofilament ProteinscardiomyocyteHybrid Rat Diversity Panelrecombinant inbredsingle-nucleotide variantsomatic cell polyploidy
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Genome-wide association mapping and targeted loss of function studies identify · full record | OpenQuestion