Evidence map›Paper›PMID 42189937›Full record

ArticleScience signaling2026

MAPK-dependent release of GDNF from Schwann cells mediates tumor-independent pain in neurofibromatosis 1.

Namrata G R Raut, Kourtney L Sprague, Aaditya Adlakha, Ashley R Rupert, Megan C Hofmann, Luis F Queme, Nancy Ratner, Michael P Jankowski

Abstract read
In one paragraph

Article in Science signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Namrata G R RautDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-8224-8269
Kourtney L SpragueDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Aaditya AdlakhaDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Ashley R RupertDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Megan C HofmannDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Luis F QuemeDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-4225-4060
Nancy RatnerDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0001-5030-9354
Michael P JankowskiDepartment of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-4700-096X

Funding

MITOGENIC ACTIVITIES IN NEUROFIBROMATOSISR01NS028840 · NINDS · UNIVERSITY OF CINCINNATI · PI NANCY RATNER · 1990 to 2026
$10.1M
Sensitization of developing sensory neurons after incisionR01NS105715 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Michael P Jankowski · 2019 to 2026
$3.3M
Mechanisms of muscle afferent sensitization after ischemiaR01NS113965 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI JANKOWSKI, MICHAEL P · 2020 to 2024
$2.4M
NINDS NIH HHS R01 NS028840NINDS NIH HHS R01 NS105715NINDS NIH HHS R01 NS113965
6 · The paper itself

Abstract

Neurofibromatosis 1 (NF1) is an inherited tumor-predisposition syndrome in which mutations in the neurofibromin gene

Indexed as

Glial Cell Line-Derived Neurotrophic FactorMAP Kinase Signaling SystemMitogen-Activated Protein KinasesNeurofibromatosis 1PainSchwann CellsAnimalsDisease Models, AnimalGlial Cell Line-Derived Neurotrophic Factor ReceptorsMiceMice, KnockoutNeurofibromin 1Gdnf protein, mouseGfra1 protein, mouseGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsMitogen-Activated Protein KinasesNeurofibromin 1

Identifiers

PMID42189937
PMCPMC13499461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.