Evidence map›Paper›PMID 42189829›Full record

ArticlePLOS digital health2026

Moving beyond the benchmarks: Five foundational principles for meaningful AI evaluation in healthcare.

Catherine G Bielick, Aya Awwad, Jacob Ellen, Laleh Jalilian, Liam G McCoy, Vishala Mishra, Esli Osmanlliu, Stephen R Pfohl, Leo A Celi

Abstract read
In one paragraph

Article in PLOS digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Catherine G BielickDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.ORCID https://orcid.org/0000-0003-1871-3909
Aya AwwadMetabolism Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Jacob EllenHarvard Medical School, Boston, Massachusetts, United States of America‌‌.
Laleh JalilianDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America.
Liam G McCoyDivision of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Vishala MishraDuke University School of Medicine, Durham, North Carolina, United States of America.
Esli OsmanlliuDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Montreal Children's Hospital, Montreal, Quebec, Canada.
Stephen R PfohlGoogle Research, Mountain View, California, United States of America.
Leo A CeliHarvard Medical School, Boston, Massachusetts, United States of America‌‌.

Funding

Predicting Morbidity and Mortality for HIV-Related Opportunistic InfectionsK08AI181606 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Catherine Bielick · 2024 to 2026
$574k
NIAID NIH HHS K08 AI181606
6 · The paper itself

Abstract

Rapid integration of Large Language Models (LLMs) into healthcare has exposed a critical disconnect between technical performance and clinical value. While state-of-the-art models achieve impressive scores on standardized medical examinations, their real-world impact remains limited, with few models progressing to successful clinical integration. This disconnect persists, in part, due to a proliferation of evaluation practices that prioritize static, decontextualized benchmarks. To help address this gap, we propose five foundational principles to guide contextually appropriate evaluations of healthcare AI: Local (grounded in specific deployment contexts), Task-specific (aligned with intended clinical use), Agile (continuously adaptive), Reflective (acknowledging limitations and inherent value-sensitivity), and Community-partnered (centering affected voices). We argue that emphasis on these principles can help shift evaluation practice towards assessment of artificial intelligence. This reorientation is essential for developing healthcare AI that not only performs well technically, but also can meaningfully improve patient care, serve communities for defined purposes, and mitigate (rather than exacerbate) health disparities.

Identifiers

PMID42189829
PMCPMC13210184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.