ArticlePloS one2026
Use of virtual reality medical hypnosis for anxiolytic purposes during frozen embryo transfer: A prospective pilot study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06016582 (Use of Virtual Reality Medical Hypnosis for Anxiolytic Purposes During Frozen Embryo Transfer - Hypno-TEC Feasibility Study), which is not on this map. Not yet cited in PubMed.
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Use of Virtual Reality Medical Hypnosis for Anxiolytic Purposes During Frozen Embryo Transfer - Hypno-TEC Feasibility Study
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6 authors.
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Abstract
objectiveTo assess the feasibility of using a virtual reality medical hypnosis (VRH) device for anxiolytic purposes during frozen embryo transfer (FET) and to observe its effect on subsequent pregnancy rate.
designThis is a prospective, single-center study conducted in a French public reproductive medicine ward between December 2023 and 1 May 2024. SUBJECTS: Women aged 18-45 years who undergoing IVF at the center. The present study included 50 women who had a scheduled FET.
interventionsStudy participants were using the VRH device during the FET. MAIN OUTCOMES MEASURES: Feasibility was defined as optimal and incident-free device use. Anxiety levels were measured pre- and post-procedure using the State-Trait Anxiety Inventory (STAI-Y1). Women and caregiver satisfaction were assessed using Likert scales, while acceptability of the procedure was assessed by recording adverse events. HCG test was conducted afterward and compared with a concurrent non-exposed cohort from the same unit and inclusion period using causal inference to analyze pregnancy rates.
results50 women were included from the active patient file undergoing FET at the center. The feasibility of using the VRH device was assessed at 96%, with 100% acceptability of the procedure. Women satisfaction was 98%, and caregiver satisfaction reached 100%, with a favorable device's use opinion in routine practice. A significant reduction in anxiety was observed, with a mean anxiety score of 28.8/80 after the procedure compared to 39.3/80 before (p < 0.001). Regarding pregnancy outcomes, 25 women had a positive HCG test after the procedure, including 20 with HCG > 100 IU/L, resulting in a pregnancy rate of 40%. Although a positive trend was observed in the comparison with the concurrent non-exposed cohort, the difference was not statistically significant (OR 1.18, 95% CI 0.65-2.14; p = 0.583).
conclusionThe use of a VRH device during FET is feasible and safe, suggesting a promising anxiolytic effect and a useful non-medical tool for optimizing care pathways in assisted reproduction. Further larger and controlled studies are warranted to confirm these encouraging findings and to more thoroughly assess the impact on pregnancy outcomes.
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