ArticleJournal of speech, language, and hearing research : JSLHR2026
Impact of Circulating Estrogen and Mild Systemic Dehydration on Ultrasonic Vocalizations in Female Rats.
Article in Journal of speech, language, and hearing research : JSLHR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeHormonal and hydration states are known to individually influence laryngeal physiology, yet their distinct and combined effects on vocal function remain poorly understood. This study investigated the interaction of reduced circulating estrogen, estradiol replacement, and mild systemic dehydration (DEHY) on ultrasonic vocalization (USV) in adult female rats.
methodForty-eight Long-Evans rats were assigned to six groups (
resultsOVX animals produced shorter duration and lower power USVs compared with controls, although total number and frequency range were largely preserved. Even after hormonal replacement, OVX + Estradiol animals emitted fewer USVs with shorter duration, narrower frequency range, and reduced power as compared with control animals. DEHY narrowed USV frequency range across hormonal groups and interacted with hormonal status to modulate USV number and duration.
conclusionsBoth circulating estrogen and systemic hydration status selectively influenced USV profiles. Although statistically significant, USV changes were generally of small magnitude, warranting caution in interpretation. These findings highlight the nuanced and context-dependent nature of endocrine and hydration influences on vocalizations and establish a preclinical framework for investigating hormone-hydration interactions in laryngeal function.
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