ArticleLasers in surgery and medicine2026
Efficacy of Berberine-Mediated Photodynamic Therapy Against Trichophyton rubrum Infection.
Article in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Efficacy of Berberine-Mediated Photodynamic Therapy Against Trichophyton rubrum Infection.Lasers in surgery and medicine · 2026Article
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8 authors.
Funding
Abstract
objectiveTo investigate the antifungal effects of berberine-mediated photodynamic therapy (BBR-PDT) against Trichophyton rubrum (T. rubrum) both in vitro and in vivo, and to elucidate its underlying mechanisms of action.
methodsThe minimum inhibitory concentration (MIC) of BBR-PDT against T. rubrum was determined according to the CLSI M38-A2 guidelines. The MTT assay was used to evaluate the effects of various BBR concentrations and light doses, with results subsequently validated by colony diameter measurements and spore germination assays. Intracellular reactive oxygen species (ROS) levels were measured using DCFH-DA, and transmission electron microscopy (TEM) was used to assess cellular damage in T. rubrum. A guinea pig skin infection model was established, and therapeutic efficacy was evaluated using clinical skin scoring, fungal culture, and histopathological analysis (H&E staining).
resultsIn vitro experiments showed that at a light dose of 96 J/cm
conclusionBBR-PDT exerts antifungal effects via ROS-mediated oxidative stress. This oxidative stress disrupts T. rubrum ultrastructure through multiple mechanisms. The therapy is effective against T. rubrum in vitro and in vivo. Therefore, BBR-PDT holds promise as a treatment for dermatophyte infections.
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