Evidence map›Paper›PMID 42189752›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Cholesterol Analogue for Cell-Surface Enzyme Display.

Vasco F Batista, Nele Van Wyngaerden, Changzhu Wu, Frank Glorius

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vasco F BatistaDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, Denmark.
Nele Van WyngaerdenOrganisch-Chemisches Institut, Universität Münster, Münster, Germany.ORCID 0000-0002-4444-8398
Changzhu WuDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, Denmark.ORCID 0000-0001-9405-5616
Frank GloriusOrganisch-Chemisches Institut, Universität Münster, Münster, Germany.ORCID 0000-0002-0648-956X

Funding

Carlsberg Foundation CF22-1008Deutsche Forschungsgemeinschaft SFB1348Independent Research Fund Denmark 9064-00062BNovo Nordisk Foundation NNF21OC0071661Novo Nordisk Foundation NNF24OC0095324
6 · The paper itself

Abstract

The cell membrane is a prime target for the introduction of novel cellular functionalities, as it is a complex system with many routes for surface modification. Several chemical coating and genetic engineering methods have thus been developed for this purpose. Here, a distinct way to enable enzyme-binding onto the surface of bacterial cells is explored using biomimetic lipids that integrate within the cell membrane. E. coli cells were equipped with a cholesterol-based artificial lipid containing a nitrilotriacetic acid (NTA) group which, when loaded with Ni

Indexed as

Cell MembraneCholesterolTransaminasesEscherichia coliGreen Fluorescent ProteinsNickelNitrilotriacetic AcidCholesterolGreen Fluorescent ProteinsNickelNitrilotriacetic AcidTransaminasesartificial lipidbiocatalysiscell engineeringCHIMhis‐tagged proteins

Identifiers

PMID42189752
PMCPMC13480830

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.