Evidence map›Paper›PMID 42189698›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Hydrophobic Tag Degraders Overcome Endocrine-Resistant Breast Cancer by Recruiting HSP27-Mediated E3 Ligase Complex for ERα Proteasomal Degradation.

Lilan Xin, Zemin Song, Yali Cui, Chao Wang, Yan Chen, Jing Liu, Jian Min, Zhiye Hu, Ruijing Xiao, Xin Liu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lilan XinDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Zemin SongTaikang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Yali CuiSchool of Sports Medicine, Wuhan Sports University, Wuhan, China.
Chao WangDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Yan ChenDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Jing LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Jian MinState Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, China.
Zhiye HuDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Ruijing XiaoTaikang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Xin LiuState Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, China.
Zhangxiao GuoDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Hongli WangDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Zheyang HuState Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan, China.
Jian HuangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Kaiwei LiangTaikang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Chune DongDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Hai-Bing ZhouDepartment of Hematology, School of Pharmaceutical Sciences, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.ORCID 0000-0001-8498-063X

Funding

Fundamental Research Funds for the Central Universities of China 2042022dx0003National Key R&D Program of China 2020YFA0908800NSFC 21721005NSFC 81373255NSFC 82073690NSFC 82100133NSFC 82173676NSFC 82273774NSFC 82473775NSFC 82530006NSFC 82574251
6 · The paper itself

Abstract

Hydrophobic tag (HyT)-mediated protein degradation has emerged as a pivotal tool for targeted protein degradation (TPD), yet its underlying degradation mechanism remains incompletely elucidated. Herein, we designed structurally optimized HyT-based degraders by covalently conjugating hydrophobic amino acid tags to ERα-targeting ligands via alkane linkers of varying lengths, identifying the lead compound VI-10h. VI-10h exhibited potent antiproliferative activity and efficient ERα degradation in endocrine-resistant breast cancer cells (LCC2, MCF-7

Indexed as

Antineoplastic AgentsBreast NeoplasmsEstrogen Receptor alphaHSP27 Heat-Shock ProteinsProteasome Endopeptidase ComplexUbiquitin-Protein LigasesAnimalsCell ProliferationDrug Resistance, NeoplasmFemaleHumansHydrophobic and Hydrophilic InteractionsMiceProteolysisAntineoplastic AgentsESR1 protein, humanEstrogen Receptor alphaHSP27 Heat-Shock ProteinsProteasome Endopeptidase ComplexUbiquitin-Protein LigasesE3 ligaseendocrine resistanceERαHSP27hydrophobic tag

Identifiers

PMID42189698
PMCPMC13383244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.