Evidence map›Paper›PMID 42189391›Full record

ArticleScience China. Life sciences2026

Creation of intermuscular bone-free genetic mutants in grass carp and multiomics reveals molecular regulatory basis.

Jun-Qi Liu, Chun-Hong Nie, Zheng-Yin Wang, Yue Yu, Dong-Yang Zhang, Jian Wang, Xue-Qiao Qian, Shi-Ming Wan, Ze-Xia Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Integrated Transcriptomic and Proteomic Analysis RevealsAnimals : an open access journal from MDPI · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun-Qi Liu *College of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.
Chun-Hong Nie *College of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.
Zheng-Yin WangCollege of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.
Yue YuCollege of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.
Dong-Yang ZhangCollege of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.
Jian WangKey Laboratory of Microecological Resources and Utilization in Breeding Industry, Ministry of Agriculture and Rural Affairs, Guangdong Haid Group Co., Ltd., Guangzhou, 511400, China.
Xue-Qiao QianKey Laboratory of Microecological Resources and Utilization in Breeding Industry, Ministry of Agriculture and Rural Affairs, Guangdong Haid Group Co., Ltd., Guangzhou, 511400, China.
Shi-Ming WanCollege of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China. wansm@mail.hzau.edu.cn.
Ze-Xia GaoCollege of Fisheries, Hubei Hongshan Laboratory, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; Engineering Technology Research Center for Fish Breeding and Culture in Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China. gaozx@mail.hzau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Grass carp (Ctenopharyngodon idellus) is an economically important fish, produced at the highest level among all freshwater aquaculture fish in the world, yet the significant number of intermuscular bones (IBs) present in the fillets severely limits its consumption and processing options. To address this limitation, we first investigated the developmental characteristics of IBs in grass carp. Our results revealed that the key period for IB ossification from myosepta occurred between 15 and 40 days post-hatching (dph). Through gene editing of runx2b, the key gene for IB development, we successfully constructed an F

Indexed as

Bone and BonesCarpsMuscle, SkeletalMutationAnimalsFemaleFish ProteinsMaleMultiomicsOsteogenesisFish Proteinsgenetic improvementgrass carpintermuscular bonemolecular regulationmuscle quality

Identifiers

PMID42189391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.