Evidence map›Paper›PMID 42189389›Full record

ArticleScience China. Life sciences2026

Efficient combined use of electroacupuncture with ordered collagen scaffolds enhances the therapeutic efficacy of human spinal cord-derived neural progenitor cells therapy in spinal cord injury rats.

Yunlong Zou, Weiwei Xue, Bo Guo, Lu Li, Yannan Zhao, Xianming Wu, Zhifeng Xiao, Qi Zhang, Dezun Ma, Xinhao Zhao and 9 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yunlong Zou *China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Weiwei Xue *Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Bo Guo *China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Lu Li *China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Yannan ZhaoLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Xianming WuChinese Institute for Brain Research, Beijing, 102206, China.
Zhifeng XiaoLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Qi ZhangLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Dezun MaAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Xinhao ZhaoDepartment of Rehabilitation Medicine and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bing ChenLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
He ShenLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Wenbo XuChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Haobo ZhangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Yanyun YinLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Ya ShiLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Yi CuiReproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 100081, China. yicui22@126.com.
Rui GuChina-Japan Union Hospital of Jilin University, Changchun, 130033, China. gurui@jlu.edu.cn.
Jianwu DaiLaboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. jwdai@genetics.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most spinal cord injury (SCI) patients experience severe morbidity and permanent disability. Currently, effective clinical treatments remain limited. Beyond direct nerve damage, spinal cord lesions result in atrophy of lower limb muscles, thereby impeding motor function recovery. Our therapeutic approach for repairing complete SCI combines traditional Chinese electroacupuncture stimulation of the Jiaji (EX-B2) and Zusanli (ST36) acupoints with the transplantation of human spinal cord-derived neural progenitor cells (hsc-NPCs) delivered on an ordered collagen scaffold. Results indicated that electroacupuncture was applied both to enhance the efficacy of hsc-NPCs therapy for nerve regeneration at the lesion site and to prevent muscle atrophy, contributing to motor function recovery. This innovative approach integrates Eastern and Western medical perspectives to pursue breakthroughs in SCI treatment.

Indexed as

electroacupuncturehuman spinal cord-derived neural progenitor cellordered collagen scaffoldspinal cord injury

Identifiers

PMID42189389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.