Evidence map›Paper›PMID 42189347›Full record

ArticleResearch on child and adolescent psychopathology2026

Perinatal Risk Factors, Allergic Conditions and Psychosocial Problems in Children and Adolescents with Mental Health Problems.

Sara Pieters, William J Burk, Helen Klip, Carolina de Weerth, Malindi van der Mheen, Gabry W Mies, Emilie M A van Tetering, Anne-Marie van den Hoek, Wendy J M A van Summeren, Wouter Staal and 1 more

Abstract read
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Article in Research on child and adolescent psychopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara PietersRadboud University, Behavioural Science Institute, Thomas Van Aquinostraat 4, Nijmegen, 6525 GD, the Netherlands. sara.pieters@ru.nl.ORCID http://orcid.org/0009-0008-5914-4048
William J BurkRadboud University, Behavioural Science Institute, Thomas Van Aquinostraat 4, Nijmegen, 6525 GD, the Netherlands.
Helen KlipKarakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, Nijmegen, 6525 GC, the Netherlands.
Carolina de WeerthRadboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, Nijmegen, 6525 EN, the Netherlands.
Malindi van der MheenDepartment of Child and Adolescent Psychiatry, Amsterdam UMC, Meibergdreef 5, Amsterdam, 1105 AZ, the Netherlands.
Gabry W MiesKenniscentrum Kinder- en Jeugdpsychiatrie, Churchilllaan 11, Utrecht, 3527 GV, the Netherlands.
Emilie M A van TeteringKarakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, Nijmegen, 6525 GC, the Netherlands.
Anne-Marie van den HoekKarakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, Nijmegen, 6525 GC, the Netherlands.
Wendy J M A van SummerenKarakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, Nijmegen, 6525 GC, the Netherlands.
Wouter StaalKarakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, Nijmegen, 6525 GC, the Netherlands.
Tinca J C PoldermanKarakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, Nijmegen, 6525 GC, the Netherlands.ORCID http://orcid.org/0000-0001-5564-301X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-related problems have been implicated in mental health disorders, yet their role in youth remains unclear. This study examined (a) the prevalence of perinatal risk factors and allergic conditions in youth receiving psychiatric care, (b) the association between these risks, and (c) their combined impact on psychosocial functioning. Participants included 2,193 children and adolescents (ages 6-17; M = 11.52, SD = 3.35). Parent-reported questionnaires assessed perinatal risks, allergic conditions, and psychosocial symptoms. Perinatal risks were reported in 31% and allergic conditions in 20% of the sample. No significant association emerged between the two risk domains. However, allergic conditions were linked to elevated internalizing symptoms. For externalizing symptoms, an effect of allergic conditions was only found in those with perinatal risks. Findings support the immuno-psychiatry framework, indicating that allergic conditions, particularly in combination with early-life risk, may contribute to psychosocial difficulties in clinically referred youth. Implications for early intervention are discussed.

Indexed as

HypersensitivityMental DisordersPsychosocial FunctioningAdolescentChildFemaleHumansMalePregnancyPrevalenceRisk FactorsAllergic conditionsMental health problemsPerinatal risk factorsYouth

Identifiers

PMID42189347
PMCPMC13212645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.