Evidence map›Paper›PMID 42189276›Full record

ArticleCancer causes & control : CCC2026

Adverse childhood experiences, adult adiposity, and risk of young-onset breast cancer subtypes in a population-based case-control study.

Lydia Marcus Post, Young Ik Cho, James Topitzes, DPhuong Do, Dorothy R Pathak, Ann S Hamilton, Amani M Nuru-Jeter, Kelly A Hirko, Jamila L Kwarteng, Richard Houang and 2 more

Abstract read
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In one paragraph

Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lydia Marcus PostEpidemiology Program, Joseph J. Zilber College of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53205, USA.ORCID http://orcid.org/0000-0003-3748-5921
Young Ik ChoCommunity & Behavioral Health Promotion Program. Joseph J. Zilber College of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0003-4632-0934
James TopitzesSocial Work Department, Helen Bader School of Social Welfare, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-2306-650X
DPhuong DoEpidemiology Program, Joseph J. Zilber College of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53205, USA.ORCID http://orcid.org/0000-0002-7551-1855
Dorothy R PathakDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-5318-3985
Ann S HamiltonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5898-2308
Amani M Nuru-JeterDivisions of Community Health Sciences & Epidemiology, School of Public Health, University of Californiaa-Berkley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-5882-1026
Kelly A HirkoDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-0050-655X
Jamila L KwartengDivision of Community Health, Institute for Health and Humanity, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-7050-4931
Richard HouangCenter for the Study of Curriculum, College of Education, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0001-5022-2275
Ann G SchwartzDepartment of Oncology, School of Medicine, Wayne State University and the Karmanos Cancer Institute, Detroit, MI, USA.
Ellen M VelieEpidemiology Program, Joseph J. Zilber College of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53205, USA. velie@uwm.edu.ORCID http://orcid.org/0000-0001-6865-9715

Funding

Life Course Energy Balance and Breast Cancer Risk in Black/White Women Under 50R01CA136861 · NCI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI VELIE, ELLEN M · 2010 to 2015
$12.4M
NCI NIH HHS R01 CA136861
6 · The paper itself

Abstract

purposeAdverse childhood experiences (ACEs) are hypothesized to increase breast cancer risk via social and physiological pathways, yet associations between ACEs and young-onset breast cancer (BC) subtypes-and potential mediators (e.g., adiposity) of these associations-are largely unstudied. We sought to evaluate associations between ACEs and young-onset BC molecular subtypes, and the potential mediating effects of adiposity, in a population-based case-control study of invasive young-onset BC.

methodsCases (n = 1,754) were identified from the Los Angeles County and Metropolitan Detroit SEER registries, 2010-2015, and area-based, frequency-matched controls (n = 1,350) sampled from the 2010 Census. Associations between ACEs aged < 18 years and young-onset BC (diagnosed ages 20 to < 50 years), overall and by subtype (luminal A, luminal B, HER2 + , triple negative [TN]), were examined using weighted logistic regression. Adult adiposity (i.e., body mass index 12 months before diagnosis, waist circumference at interview) was evaluated as a mediator of these associations using weighted path analyses.

resultsACEs (≥ 1 vs 0) were not significantly associated with young-onset BC (all p

conclusionsBereavement during childhood was associated with higher odds of HER2 + young-onset BC, and there was some evidence of an association between ACEs and other young-onset BC subtypes, particularly TN.

Indexed as

AdiposityAdverse Childhood ExperiencesBreast NeoplasmsAdultAge of OnsetCase-Control StudiesFemaleHumansLos AngelesMiddle AgedRisk FactorsSEER ProgramYoung AdultAdult adiposityAdverse childhood experiencesTumor subtypesYoung onset breast cancer

Identifiers

PMID42189276
PMCPMC13212395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.