Evidence map›Paper›PMID 42189206›Full record

ArticleEuropean child & adolescent psychiatry2026

Differentiating tics and functional tic-like behaviours in children and young people: personal and family mental health profiles and their clinical implications.

Holan Liang, Savva Pronin, Morvwen Duncan, Lila Simpson, Abbie Smith, Katie Harrold, Zoe Pearman, Amy Warren, Sara Shavel-Jessop, Tara Murphy and 3 more

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Article in European child & adolescent psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Holan LiangTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK. hll20@cam.ac.uk.ORCID http://orcid.org/0000-0001-6650-9449
Savva ProninUniversity College London Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-3502-5334
Morvwen DuncanTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0000-0002-5220-8546
Lila SimpsonTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0009-0001-1886-3926
Abbie SmithTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0009-0006-6131-6844
Katie HarroldTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0009-0000-4287-1312
Zoe PearmanTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0009-0001-7486-7235
Amy WarrenTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0009-0005-5673-7073
Sara Shavel-JessopTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0009-0007-2037-6282
Tara MurphyTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0000-0003-1759-3562
Isobel HeymanTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0000-0001-7358-9766
Sacha EvansTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0000-0002-5113-8005
Matteo CatanzanoTic Service, Psychological and Mental Health Services, Great Ormond Street Hospital, London, UK.ORCID http://orcid.org/0000-0002-7876-4348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPersonal and family mental health histories of youth with functional tic-like behaviours (FTLB) and/or tics (TS) were compared.

methodThis is a cross-sectional study with between-group analysis of 127 patients aged 4-17 years referred to a tic service between 2019 and 2022 who were diagnosed with FTLB, TS, or co-occurring FTLB and TS. Co-occurring psychiatric and neurodevelopmental conditions in the personal and family history of cases collected prospectively were recorded as per standard care. Post-hoc analysis was undertaken to explore findings of interest.

resultsLater tic onset (13 years vs. 5 years) and increased comorbid psychiatric disorders (> 78% vs. 51%) in the FTLB versus TS groups, support the European Society for the Study of Tourette Syndrome (ESSTS) criteria for clinical diagnosis of FTLBs. Anxiety, depression and autism were more prominent in FTLB groups. 35% of the FTLB group had an ADHD diagnosis. Family history of tics is significantly more likely in the TS groups, while family history of anxiety was most prominent in the TS+FTLB group. Post hoc analysis indicated that in FTLB with co-occurring ADHD, the majority of ADHD (56%) was picked up following FTLB presentation, with missed ADHD diagnoses mainly in girls. DISCUSSION: Patterns of difference in mental health and family mental health exist between TS and FTLB supporting ESSTS diagnostic criterion for FTLB. FTLB is associated with anxiety, depression and autism. ADHD is present in 35% of FTLB even without TS, and if this is a replicable finding, suggests a treatable vulnerability factor in FTLB.

Indexed as

Attention-deficit hyperactivity disorderAutismCross-sectional studyDemographicsFunctional tic-like behavioursTourette’s syndrome

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.