Evidence map›Paper›PMID 42189193›Full record

GuidelineClinical neuroradiology2026

Expert Panel Consensus Guidelines of the German Society of Neuroradiology on the Use of Magnetic Resonance Imaging in the Diagnosis and Monitoring of Multiple Sclerosis.

Mike P Wattjes, Carsten Lukas, Sönke Langner, Hagen H Kitzler, Michael Scheel, Andreas J Bartsch, Benedikt Wiestler

Abstract readConsensus StatementPractice GuidelineReview
In one paragraph

Guideline in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mike P WattjesDept. of Neuroradiology, Charité - University Medicine Berlin, Berlin, Germany. mike.wattjes@charite.de.
Carsten LukasInstitute of Neuroradiology, Ruhr University Bochum, Bochum, Germany.
Sönke LangnerEnradia, Greifswald, Germany.
Hagen H KitzlerDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Carl Gustav Carus, Dresden, Germany.
Michael ScheelDept. of Neuroradiology, Charité - University Medicine Berlin, Berlin, Germany.
Andreas J BartschRadiologie Bamberg, Bamberg, Germany.
Benedikt WiestlerInstitute of Neuroradiology, TUM University Hospital, Munich, Germany. b.wiestler@tum.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recently published 2024 revisions of the McDonald criteria unified and expanded the diagnosis of MS towards a "biological diagnosis" and incorporated new MR imaging (bio)markers. Most prominently, they now incorporate imaging of the optic nerve as the fifth topography for dissemination in space (DIS), as well as the central vein sign (CVS) and paramagnetic rim lesions (PRLs), to facilitate an earlier diagnosis of MS. In addition, certain new MRI measures, such as slowly expanding lesions (SELs) and particularly PRLs, are increasingly used in clinical trials and may enter routine clinical practice in the near future. These developments, along with the 2024 MAGNIMS-NAIMS-CMSC consensus recommendations, suggest a different role for MRI in managing patients with MS and expansion of the MRI acquisition protocols, reading, and interpretation. Here, an imaging expert panel of the German Society of Neuroradiology (DGNR) established consensus recommendations on the role of MRI in the management of patients with suspected or definite MS, endorsed by the German Society of Neurology (DGN). These recommendations incorporate these new developments into the context of the German healthcare system. We suggest minor modifications to the acquisition protocol outlined in the 2024 McDonald criteria and the MAGNIMS-NAIMS-CMSC consensus recommendations. For patients with inconclusive imaging findings and in specific diagnostic situations, we recommend changes to MRI acquisition protocols that incorporate susceptibility-weighted imaging (SWI) sequences to demonstrate CVS and PRLs, as well as optic nerve imaging. Additionally, we provide recommendations on the use of MRI for treatment monitoring, including progressive MS patients.

Indexed as

Magnetic Resonance ImagingMultiple SclerosisGermanyHumansSocieties, MedicalCentral vein signDissemination in space and timeMcDonald criteria to diagnose MS (2024 revisions)Paramagnetic rim lesionsSusceptibility-weighted imaging

Identifiers

PMID42189193
PMCPMC13522060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.