ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes by Targeting PF4
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti-inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate. We have demonstrated that AP disrupts the balance of the gut microbiota that aggravates disease progression; however, the role of gut microbiota in the development of SIRS/CARS remains poorly understood. Here, we observed a lower abundance of Bacteroides thetaiotaomicron (B. thetaiotaomicron) that increased the infiltration of PF4
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