Evidence map›Paper›PMID 42188992›Full record

Trial reportClinical and experimental dental research2026

Clinical Evaluation of Three Direct Pulp Capping Materials in Caries-Induced Pulpitis of Mature Permanent Teeth: A Randomized Controlled Trial.

Yutong Li, Kangrui Zeng, Boshu Chen, Qiongyi Kang, Lili Huang, Hong Huang, Tingting Li, Yueping Pan, Shujun Ran, Wenwei Xia

Abstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yutong LiDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.ORCID 0009-0007-3528-1294
Kangrui ZengDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Boshu ChenDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Qiongyi KangDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Lili HuangDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Hong HuangDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Tingting LiDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Yueping PanDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Shujun RanDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Wenwei XiaDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

Funding

Shanghai Municipal Health Commission 202340174Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine KQYJXK2020
6 · The paper itself

Abstract

objectivesDirect pulp capping (DPC) preserves pulp vitality in caries-exposed permanent teeth, but clinical evidence comparing different capping materials and identifying prognostic factors remains limited. This study evaluated the success of DPC with iRoot BP Plus, mineral trioxide aggregate (MTA), and calcium hydroxide (CH), and explored factors associated with treatment outcomes. MATERIAL AND

methodsIn this single-blind, parallel-group, superiority randomized trial, 120 patients with caries-induced reversible pulpitis were equally assigned to CH, MTA, or iRoot BP Plus. The primary outcome was 12-month success, defined by combined clinical and radiographic criteria. Associations between baseline clinical factors and 12-month success were evaluated. Secondary analyses included success at 3 and 6 months.

resultsAt 12 months, 81 of 120 randomized patients (67.5%) were available for evaluation. The overall success rate was 88.9%. Success rates were 88.5% for iRoot BP Plus (n = 26), 93.1% for MTA (n = 29), and 84.6% for CH (n = 26), with no significant differences between groups (p = 0.6). Failures were significantly associated with lesions confined to the proximal surface (p = 0.001) at 12 months, while exposure size > 1 mm (p = 0.024) and anterior teeth (p = 0.018) were additional risk factors at 6 months. Kaplan-Meier analysis showed high survival across all groups (log-rank p = 0.66) and confirmed the influence of these risk factors. No adverse events were reported.

conclusionsDPC achieved high short-term success in mature permanent teeth in MTA, CH, and iRoot BP Plus. Prognostic factors such as caries location, tooth position, and exposure size remain critical for case selection.

trial registrationnumber: ChiCTR2100047588; Chinese Clinical Trial Register.

Indexed as

Calcium CompoundsCalcium HydroxideDental CariesDental Pulp CappingOxidesPulp Capping and Pulpectomy AgentsPulpitisAdolescentAdultAluminum CompoundsDentition, PermanentDrug CombinationsFemaleHumansMaleMiddle AgedAluminum CompoundsCalcium CompoundsCalcium HydroxideDrug CombinationsiRoot BP Plusmineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsSilicatescalcium hydroxidedirect pulp cappingiRoot BP Plusmineral trioxide aggregatereversible pulpitis

Identifiers

PMID42188992
PMCPMC13239863

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.