ArticleVeterinary sciences2026
The HIF-Mediated PI3K-AKT Signaling Pathway Is a Key Signaling Pathway Triggering Testicular Spermatogenic Disorders in Yaks with Cryptorchidism.
Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptorchidism is one of the major reproductive diseases affecting testicular function in yaks. However, the mechanisms underlying its impact on testicular spermatogenesis remain unclear. In this study, high-throughput transcriptomics (RNA-seq) and proteomics technologies were employed to analyze the key signaling pathways involved in cryptorchidism-induced spermatogenic dysfunction in yak, and a mouse model was established for validation. The results indicate that differentially expressed genes (DEGs) in the testes of yak with cryptorchidism are primarily enriched in the hypoxia-inducible factor (HIF) signaling pathway and the PI3K-AKT signaling pathway. Experimental results from the hypoxic mouse model indicate that the hypoxic environment remarkably raised HIF-1α content in the blood of mice while activating the PI3K-AKT signaling pathway, accompanied by decreased testicular expression of the cell adhesion molecules (CAMs) claudin 2, claudin 3, E-cadherin, and N-cadherin. Cell culture experiments showed that cell adhesion molecule expression was significantly downregulated when HIF-1α and PI3K expression were inhibited among mouse Sertoli cells, indicating that the HIF-1α/PI3K-AKT signaling pathway regulated cell adhesion molecule expression among mouse testes. Decreased CAMs directly affect tight junctions and the adhesion of spermatogenic and Sertoli cells, thus affecting sperm production and potentially also testis development. This study provides data to support research on the regulatory mechanisms involved in reproductive function and hypoxia adaptation in male animals in a low-oxygen environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.