Evidence map›Paper›PMID 42188925›Full record

ArticleVeterinary sciences2026

Efficient and Safe Knockout of

Xiaori Gao, Na Tang, Zhifeng Zhao, Yanhua He, Yitong Shen, Xian Zou, Chenglong Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaori GaoCollege of Animal Science and Technology, Foshan University, Foshan 528225, China.
Na TangKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Zhifeng ZhaoGuangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Academy of Agricultural Sciences, Institute of Animal Science, Guangzhou 510640, China.ORCID 0000-0002-1145-1638
Yanhua HeGuangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Academy of Agricultural Sciences, Institute of Animal Science, Guangzhou 510640, China.
Yitong ShenKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Xian ZouGuangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Academy of Agricultural Sciences, Institute of Animal Science, Guangzhou 510640, China.
Chenglong LuoGuangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Academy of Agricultural Sciences, Institute of Animal Science, Guangzhou 510640, China.

Funding

, the Horizontal Project of Guangdong Polytechnic of Science and Trade GDKM-2022-A-49the key research platforms and projects for ordinary universities in Guangdong Province in 2023 2023ZDZX4098the Program for Doctoral Scientific Research Start-up Funds of Guangdong Polytechnic of Science and Trade GDKM2022-94the "Youth Top-notch Talent on Science & Technology" of Guangdong Province Special Support Program 2016TQ03N898
6 · The paper itself

Abstract

This study aimed to establish an efficient and precise cytosine base editor (CBE)-mediated knockout system in chicken somatic cells and primordial germ cells (PGCs). PGCs are pivotal for generating genome-edited chickens, but low transfection efficiency limit their application. Unlike CRISPR/Cas9, CBEs achieve precise C-to-T conversion without DNA double-strand breaks or donor templates, making them safer for avian genome engineering. We used CBEs to introduce premature stop codons in exon 1 of the sex-determining

Indexed as

AR geneavian biotechnologychickencytosine base editor (CBE)DMRT1 genegene knockoutprimordial germ cells (PGCs)sgRNA screening

Identifiers

PMID42188925
PMCPMC13211467

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.